Recombinant Human FTO Protein, His-tagged
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| Cat.No. : | FTO-14H |
| Product Overview : | Recombinant human FTO protein (32-505) with a N-terminal His-tag was expressed in E. coli. |
| Description : | This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | 50 mM HEPES, pH 8.0, with 150 mM sodium choride and 10% glycerol |
| Molecular Mass : | 56.68 kDa |
| Protein length : | 32-505 |
| Purity : | ≥80% estimated by SDS-PAGE |
| Applications : | WB |
| Stability : | ≥ 1 year |
| Storage : | Store at -80 centigrade |
| SDS-PAGE of FTO : |
Lane 1: MW Markers, Lane 2: FTO (4 µg), Lane 3: FTO (2 µg). Representative gel image shown; actual purity may vary between each batch. |
| Gene Name : | FTO FTO alpha-ketoglutarate dependent dioxygenase [ Homo sapiens (human) ] |
| Official Symbol : | FTO |
| Synonyms : | FTO; FTO alpha-ketoglutarate dependent dioxygenase; GDFD; ALKBH9; BMIQ14; alpha-ketoglutarate-dependent dioxygenase FTO; AlkB homolog 9; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO |
| Gene ID : | 79068 |
| mRNA Refseq : | NM_001080432 |
| Protein Refseq : | NP_001073901 |
| MIM : | 610966 |
| UniProt ID : | Q9C0B1 |
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