Recombinant Human GABRB2, His-tagged

• Cat.No.: GABRB2-13098H
• Product Overview: Recombinant Human GABRB2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 409-471a.a.
• Description: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 [ Homo sapiens ]
• Official Symbol: GABRB2
• Synonyms: GABRB2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor; beta 2; GABA(A) receptor, beta 2; GABA(A) receptor subunit beta-2; gamma-aminobutyric acid A receptor beta 2; MGC119386; MGC119388; MGC119389
• Gene ID: 2561
• mRNA Refseq: NM_000813
• Protein Refseq: NP_000804
• MIM: 600232
• UniProt ID: P47870
• Chromosome Location: 5q34
• Pathway: GABA A receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; GABAergic synapse, organism-specific biosystem; GABAergic synapse, conserved biosystem; Ion channel transport, organism-specific biosystem; Ligand-gated ion channel transport, organism-specific biosystem; Morphine addiction, organism-specific biosystem
• Function: GABA-A receptor activity; chloride channel activity; inhibitory extracellular ligand-gated ion channel activity; ion channel activity; receptor activity