Active Recombinant Human GDF1 Protein
Cat.No. : | GDF1-045H |
Product Overview : | The mature recombinant human GDF-1 protein (254-372aa) without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured by its ability to induce Smad2 phosphorylation in P19 mouse embryonal carcinoma cells. 50 ng/mL of Recombinant Human GDF-1 can effectively induce Smad2 phosphorylation. |
Molecular Mass : | 12.6 kDa |
Product-Related Proteins : | 254-372 |
Endotoxin : | < 0.1 EU/μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | PBS |
Gene Name : | GDF1 growth differentiation factor 1 [ Homo sapiens (human) ] |
Official Symbol : | GDF1 |
Synonyms : | GDF1; growth differentiation factor 1; RAI; DORV; LAG1; UOG1; CERS1; CHTD6; DTGA3; LASS1; embryonic growth/differentiation factor 1; Ceramide synthase 1; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1 |
Gene ID : | 2657 |
mRNA Refseq : | NM_001492 |
Protein Refseq : | NP_001483 |
MIM : | 602880 |
UniProt ID : | P27539 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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