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Active Recombinant Human GDF3 Protein

Cat.No. : GDF3-048H
Product Overview : The mature recombinant human GDF-3 protein (251-364aa) without tag was expressed in E. coli.
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  • Gene Information
  • Related Products
Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients.
Source : E. coli
Species : Human
Bio-activity : Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/mL.
Molecular Mass : 12.9 kDa
Product-Related Proteins : 251-364
Endotoxin : < 0.1 EU/μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Gene Name : GDF3 growth differentiation factor 3 [ Homo sapiens (human) ]
Official Symbol : GDF3
Synonyms : GDF3; growth differentiation factor 3; KFS3; MCOP7; MCOPCB6; growth/differentiation factor 3
Gene ID : 9573
mRNA Refseq : NM_020634
Protein Refseq : NP_065685
MIM : 606522
UniProt ID : Q9NR23

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Explain the crosstalk between GDF3 signaling and other cellular pathways. 04/08/2022

GDF3 signaling may crosstalk with Wnt, Notch, and other signaling pathways, modulating their activities and integrating them into a complex regulatory network during development.

Discuss the role of GDF3 in organogenesis and tissue development during embryogenesis. 02/18/2021

GDF3 is implicated in organogenesis, influencing the development of various tissues and organs, including the heart, nervous system, and mesoderm-derived structures.

Explain the post-translational modifications involved in regulating GDF3 activity. 05/27/2020

Post-translational modifications, such as glycosylation and phosphorylation, play roles in regulating GDF3 activity, influencing its stability, secretion, and interaction with receptors.

What are the signaling pathways activated by GDF3, and how do they contribute to cellular processes? 09/11/2019

GDF3 activates the SMAD signaling pathway, influencing cellular processes such as proliferation, differentiation, and apoptosis, especially during early embryonic development.

How is GDF3 involved in the regulation of germ cell development and fertility? 12/15/2018

GDF3 is essential for germ cell development and contributes to the establishment of primordial germ cells, influencing fertility and reproductive success.

Customer Reviews (3)

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Reviews
01/14/2022

    Quick service response—customer support helped us navigate product options.

    06/21/2019

      Speedy delivery! Received this product in excellent condition, ready to use.

      12/07/2018

        This protein's consistent performance is a testament to its quality.

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