Active Recombinant Human GDF3 Protein
Cat.No. : | GDF3-048H |
Product Overview : | The mature recombinant human GDF-3 protein (251-364aa) without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/mL. |
Molecular Mass : | 12.9 kDa |
Product-Related Proteins : | 251-364 |
Endotoxin : | < 0.1 EU/μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | PBS |
Gene Name : | GDF3 growth differentiation factor 3 [ Homo sapiens (human) ] |
Official Symbol : | GDF3 |
Synonyms : | GDF3; growth differentiation factor 3; KFS3; MCOP7; MCOPCB6; growth/differentiation factor 3 |
Gene ID : | 9573 |
mRNA Refseq : | NM_020634 |
Protein Refseq : | NP_065685 |
MIM : | 606522 |
UniProt ID : | Q9NR23 |
Products Types
◆ Recombinant Protein | ||
GDF3-271H | Recombinant Human GDF3 Protein, His-tagged | +Inquiry |
GDF3-3520M | Recombinant Mouse GDF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF3-4825H | Recombinant Human GDF3 Protein, GST-tagged | +Inquiry |
Gdf3-273R | Recombinant Rat Gdf3 Protein, His-tagged | +Inquiry |
Gdf3-272M | Recombinant Mouse Gdf3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GDF3-5969HCL | Recombinant Human GDF3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionGDF3 signaling may crosstalk with Wnt, Notch, and other signaling pathways, modulating their activities and integrating them into a complex regulatory network during development.
GDF3 is implicated in organogenesis, influencing the development of various tissues and organs, including the heart, nervous system, and mesoderm-derived structures.
Post-translational modifications, such as glycosylation and phosphorylation, play roles in regulating GDF3 activity, influencing its stability, secretion, and interaction with receptors.
GDF3 activates the SMAD signaling pathway, influencing cellular processes such as proliferation, differentiation, and apoptosis, especially during early embryonic development.
GDF3 is essential for germ cell development and contributes to the establishment of primordial germ cells, influencing fertility and reproductive success.
Customer Reviews (3)
Write a reviewQuick service response—customer support helped us navigate product options.
Speedy delivery! Received this product in excellent condition, ready to use.
This protein's consistent performance is a testament to its quality.
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