Recombinant Human GDNF Protein, His-tagged
Cat.No. : | GDNF-01H |
Product Overview : | Recombinant human GDNF (109-211aa), fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
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Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Liquid |
Molecular Mass : | 12.8kDa (113aa) |
Protein length : | 109-211aa |
AA Sequence : | |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 90% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by Absorbance at 280nm) |
Storage Buffer : | In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol. |
Gene Name : | GDNF glial cell derived neurotrophic factor [ Homo sapiens (human) ] |
Official Symbol : | GDNF |
Synonyms : | GDNF; glial cell derived neurotrophic factor; ATF; ATF1; ATF2; HSCR3; HFB1-GDNF; glial cell line-derived neurotrophic factor; astrocyte-derived trophic factor |
Gene ID : | https://www.ncbi.nlm.nih.gov/gene/2668 |
mRNA Refseq : | https://www.ncbi.nlm.nih.gov/nuccore/NM_000514.4 |
Protein Refseq : | https://www.ncbi.nlm.nih.gov/protein/NP_000505.1 |
MIM : | https://omim.org/entry/600837 |
UniProt ID : | https://www.uniprot.org/uniprotkb/P39905/entry |
Products Types
◆ Recombinant Protein | ||
Gdnf-30M | Recombinant Mouse Gdnf Protein (Ser78-Ile211), C-His tagged, Animal-free, Carrier-free | +Inquiry |
GDNF-7292H | Active Recombinant Human GDNF protein(Arg83-Ile185) | +Inquiry |
GDNF-18H | Recombinant Human GDNF Protein | +Inquiry |
Gdnf-1574M | Recombinant Mouse Gdnf Protein, His-tagged | +Inquiry |
GDNF-054H | Active Recombinant Human GDNF Protein | +Inquiry |
◆ Lysates | ||
GDNF-400RCL | Recombinant Rat GDNF cell lysate | +Inquiry |
GDNF-1549HCL | Recombinant Human GDNF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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