Recombinant Human GFRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | GFRA1-1312H |
| Product Overview : | GFRA1 MS Standard C13 and N15-labeled recombinant protein (NP_001138925) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 50.84 kDa |
| AA Sequence : | MFLATLYFAL PLLDLLLSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF SLASGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRVVPFISV EHIPKGNNCL DAAKACNLDD ICKKYRSAYI TPCTTSVSND VCNRRKCHKA LRQFFDKVPA KHSYGMLFCS CRDIACTERR RQTIVPVCSY EEREKPNCLN LQDSCKTNYI CRSRLADFFT NCQPESRSVS SCLKENYADC LLAYSGLIGT VMTPNYIDSS SLSVAPWCDC SNSGNDLEEC LKFLNFFKDN TCLKNAIQAF GNGSDVTVWQ PAFPVQTTTA TTTTALRVKN KPLGPAGSEN EIPTHVLPPC ANLQAQKLKS NVSGNTHLCI SNGNYEKEGL GASSHITTKS MAAPPSCGLS PLLVLVVTAL STLLSLTETS TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | GFRA1 GDNF family receptor alpha 1 [ Homo sapiens (human) ] |
| Official Symbol : | GFRA1 |
| Synonyms : | GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; GFR-ALPHA-1; FLJ10561; FLJ31546; MGC23045; DKFZp313E1012; DKFZp686J0156; |
| Gene ID : | 2674 |
| mRNA Refseq : | NM_001145453 |
| Protein Refseq : | NP_001138925 |
| MIM : | 601496 |
| UniProt ID : | P56159 |
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| GFRA1-4860H | Recombinant Human GFRA1 Protein, GST-tagged | +Inquiry |
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◆ Lysates
| GFRA1-2426HCL | Recombinant Human GFRA1 cell lysate | +Inquiry |
| GFRA1-961RCL | Recombinant Rat GFRA1 cell lysate | +Inquiry |
| GFRA1-2692MCL | Recombinant Mouse GFRA1 cell lysate | +Inquiry |
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