Recombinant Human GFRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: GFRA1-1312H
• Product Overview: GFRA1 MS Standard C13 and N15-labeled recombinant protein (NP_001138925) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 50.84 kDa
• AA Sequence: MFLATLYFALPLLDLLLSAEVSGGD RLDCVKASDQCLKEQSCSTKYRTLR QCVAGKETNFSLASGLEAKDECRSA MEALKQKSLYNCRCKRGMKKEKNCL RIYWSMYQSLQGNDLLEDSPYEPVN SRLSDIFRVVPFISVEHIPKGNNCL DAAKACNLDDICKKYRSAYITPCTT SVSNDVCNRRKCHKALRQFFDKVPA KHSYGMLFCSCRDIACTERRRQTIV PVCSYEEREKPNCLNLQDSCKTNYI CRSRLADFFTNCQPESRSVSSCLKE NYADCLLAYSGLIGTVMTPNYIDSS SLSVAPWCDCSNSGNDLEECLKFLN FFKDNTCLKNAIQAFGNGSDVTVWQ PAFPVQTTTATTTTALRVKNKPLGP AGSENEIPTHVLPPCANLQAQKLKS NVSGNTHLCISNGNYEKEGLGASSH ITTKSMAAPPSCGLSPLLVLVVTAL STLLSLTETSTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: GFRA1 GDNF family receptor alpha 1 [ Homo sapiens (human) ]
• Official Symbol: GFRA1
• Synonyms: GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; GFR-ALPHA-1; FLJ10561; FLJ31546; MGC23045; DKFZp313E1012; DKFZp686J0156
• Gene ID: 2674
• mRNA Refseq: NM_001145453
• Protein Refseq: NP_001138925
• MIM: 601496
• UniProt ID: P56159