Recombinant Human GFRAL Protein, Fc-tagged
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| Cat.No. : | GFRAL-001H |
| Product Overview : | The extracellular domain of human GFRAL (aa 19-351) fused to the N-terminus of the Fc region of human IgG1 was expressed in HEK 293 cells. |
| Description : | GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Human GFR α-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance. |
| Source : | HEK 293 Cells |
| Species : | Human |
| Tag : | Fc |
| Bio-activity : | Measured by its binding ability in a functional ELISA. |
| Molecular Mass : | 25 kDa |
| Endotoxin : | <0.06 EU/μg purified protein. |
| Purity : | ≥98% (SDS-PAGE) |
| Stability : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. Avoid freeze/thaw cycles. |
| Storage : | Short term storage at +4 centigrade, long term storage at -20 centigrade. |
| Storage Buffer : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping : | BLUE ICE |
| Gene Name : | GFRAL GDNF family receptor alpha like [ Homo sapiens (human) ] |
| Official Symbol : | GFRAL |
| Synonyms : | GFRAL; GDNF family receptor alpha like; GRAL; UNQ9356; C6orf144; bA360D14.1; GDNF family receptor alpha-like; IVFI9356 |
| Gene ID : | 389400 |
| mRNA Refseq : | NM_207410 |
| Protein Refseq : | NP_997293 |
| MIM : | 617837 |
| UniProt ID : | Q6UXV0 |
◆ Recombinant Protein
| GFRAL-22H | Recombinant Human GFRAL Protein, His-tagged | +Inquiry |
| GFRAL-6321M | Recombinant Mouse Gfral Protein, Fc-tagged | +Inquiry |
| GFRAL-1929H | Recombinant Human GFRAL Protein (19-351 aa), His-SUMO-tagged | +Inquiry |
| GFRAL-60H | Recombinant Human GFRAL protein, His-Avi-tagged | +Inquiry |
| Gfral-060M | Recombinant Mouse Gfral protein, His-Avi-tagged | +Inquiry |
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