Recombinant Human GFRAL Protein, Fc-tagged
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|Product Overview :||The extracellular domain of human GFRAL (aa 19-351) fused to the N-terminus of the Fc region of human IgG1 was expressed in HEK 293 cells.|
|Description :||GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Human GFR α-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.|
|Source :||HEK 293 Cells|
|Bio-activity :||Measured by its binding ability in a functional ELISA.|
|Molecular Mass :||25 kDa|
|Endotoxin :||<0.06 EU/μg purified protein.|
|Purity :||≥98% (SDS-PAGE)|
|Stability :||Stable for at least 1 year after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Avoid freeze/thaw cycles.
|Storage :||Short term storage at +4 centigrade, long term storage at -20 centigrade.|
|Storage Buffer :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Reconstitution :||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping :||BLUE ICE|
|Gene Name :||GFRAL GDNF family receptor alpha like [ Homo sapiens (human) ]|
|Official Symbol :||GFRAL|
|Synonyms :||GFRAL; GDNF family receptor alpha like; GRAL; UNQ9356; C6orf144; bA360D14.1; GDNF family receptor alpha-like; IVFI9356|
|Gene ID :||389400|
|mRNA Refseq :||NM_207410|
|Protein Refseq :||NP_997293|
|UniProt ID :||Q6UXV0|
◆ Recombinant Protein
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