| Cat.No. : |
GFRAL-001H |
| Product Overview : |
The extracellular domain of human GFRAL (aa 19-351) fused to the N-terminus of the Fc region of human IgG1 was expressed in HEK 293 cells. |
| Description : |
GFRAL (GDNF receptor α-like) is a distant member of the GDNFR family of proteins. Human GFR α-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance. |
| Source : |
HEK 293 Cells |
| Species : |
Human |
| Tag : |
Fc |
| Bio-activity : |
Measured by its binding ability in a functional ELISA. |
| Molecular Mass : |
25 kDa |
| Endotoxin : |
<0.06 EU/μg purified protein. |
| Purity : |
≥98% (SDS-PAGE) |
| Stability : |
Stable for at least 1 year after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Avoid freeze/thaw cycles. |
| Storage : |
Short term storage at +4 centigrade, long term storage at -20 centigrade. |
| Storage Buffer : |
Lyophilized from 0.2μm-filtered solution in PBS. |
| Reconstitution : |
Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping : |
BLUE ICE |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.