Recombinant Human GLS Protein, GST-tagged
Cat.No. : | GLS-4979H |
Product Overview : | Human GLS partial ORF ( NP_055720, 580 a.a. - 669 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
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Description : | Sahai (1983) [PubMed 6825316] demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter (Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) [PubMed 6682827] who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.[supplied by OMIM |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 35.64 kDa |
AA Sequence : | EQRDYDSRTALHVAAAEGHVEVVKF LLEACKVNPFPKDRWNNTPMDEALH FGHHDVFKILQEYQVQYTPQGDSDN GKENQTVHKNLDGLL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GLS glutaminase [ Homo sapiens ] |
Official Symbol : | GLS |
Synonyms : | GLS; glutaminase; glutaminase kidney isoform, mitochondrial; GLS1; KIAA0838; K-glutaminase; glutaminase C; L-glutamine amidohydrolase; glutaminase, phosphate-activated; GAC; GAM; KGA; AAD20; FLJ10358; FLJ41499; DKFZp686D14231; DKFZp686O15119; |
Gene ID : | 2744 |
mRNA Refseq : | NM_001256310 |
Protein Refseq : | NP_001243239 |
MIM : | 138280 |
UniProt ID : | O94925 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGLS catalyzes the conversion of glutamine to glutamate, playing a crucial role in amino acid metabolism.
GLS is vital for neurotransmitter production, influencing glutamate and GABA levels.
It facilitates glutaminolysis, enabling cells to utilize glutamine for energy and biosynthesis.
In cancer, upregulated GLS supports rapid proliferation by fueling energy and biosynthetic pathways.
Therapeutic strategies targeting GLS aim to inhibit its activity, especially in glutamine-dependent cancers.
GLS activity contributes to cellular ATP production by providing intermediates for the TCA cycle.
GLS is highly expressed in tissues with rapid cell division and high metabolic rates, such as cancer cells.
Customer Reviews (3)
Write a reviewHighly recommend for experiments.
Worked well, good quality.
Satisfied with product performance.
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