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Recombinant Human GLS Protein, GST-tagged

Cat.No. : GLS-4979H
Product Overview : Human GLS partial ORF ( NP_055720, 580 a.a. - 669 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Sahai (1983) [PubMed 6825316] demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter (Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) [PubMed 6682827] who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.[supplied by OMIM
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 35.64 kDa
AA Sequence : EQRDYDSRTALHVAAAEGHVEVVKF LLEACKVNPFPKDRWNNTPMDEALH FGHHDVFKILQEYQVQYTPQGDSDN GKENQTVHKNLDGLL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : GLS glutaminase [ Homo sapiens ]
Official Symbol : GLS
Synonyms : GLS; glutaminase; glutaminase kidney isoform, mitochondrial; GLS1; KIAA0838; K-glutaminase; glutaminase C; L-glutamine amidohydrolase; glutaminase, phosphate-activated; GAC; GAM; KGA; AAD20; FLJ10358; FLJ41499; DKFZp686D14231; DKFZp686O15119;
Gene ID : 2744
mRNA Refseq : NM_001256310
Protein Refseq : NP_001243239
MIM : 138280
UniProt ID : O94925

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the main function of GLS in cellular metabolism? 02/14/2022

GLS catalyzes the conversion of glutamine to glutamate, playing a crucial role in amino acid metabolism.

What role does GLS play in neurotransmitter production? 10/19/2021

GLS is vital for neurotransmitter production, influencing glutamate and GABA levels.

How does GLS contribute to glutaminolysis? 09/04/2021

It facilitates glutaminolysis, enabling cells to utilize glutamine for energy and biosynthesis.

How is GLS activity implicated in cancer cell proliferation? 03/03/2021

In cancer, upregulated GLS supports rapid proliferation by fueling energy and biosynthetic pathways.

Are there therapeutic strategies targeting GLS in disease treatment? 02/27/2021

Therapeutic strategies targeting GLS aim to inhibit its activity, especially in glutamine-dependent cancers.

What is the relationship between GLS activity and cellular energy production? 06/20/2020

GLS activity contributes to cellular ATP production by providing intermediates for the TCA cycle.

In which tissues is GLS highly expressed? 03/30/2020

GLS is highly expressed in tissues with rapid cell division and high metabolic rates, such as cancer cells.

Customer Reviews (3)

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Reviews
11/23/2022

    Highly recommend for experiments.

    08/20/2021

      Worked well, good quality.

      05/29/2021

        Satisfied with product performance.

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