Recombinant Human GRAP2, His-tagged

• Cat.No.: GRAP2-27308TH
• Product Overview: Recombinant full length Human GRAP2 with an N terminal His tag; 350 amino acids with tag, MWt 40.0 kDa.

Specification

• Description: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
• Protein length: 330 amino acids
• Conjugation: HIS
• Molecular Weight: 40.000kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 30% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, 1mM EDTA, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMEAVA KFDFTASGEDELSFHTGDVLKILSN QEEWFKAELGSQEGYVPKNFIDIQF PKWFHEGLSRHQAENLLMGKEVGFF IIRASQSSPGDFSISVRHEDDVQHF KVMRDNKGNYFLWTEKFPSLNKLVD YYRTNSISRQKQIFLRDRTREDQGH RGNSLDRRSQGGPHLSGAVGEEIRP SMNRKLSDHPPTLPLQQHQHQPQPP QYAPAPQQLQQPPQQRYLQHHHFHQ ERRGGSLDINDGHCGTGLGSEMNAA LMHRRHTDPVQLQAAGRVRWARALY DFEALEDDELGFHSGEVVEVLDSSN PSWWTGRLHNKLGLFPANYVAPMTR
• Sequence Similarities: Belongs to the GRB2/sem-5/DRK family.Contains 1 SH2 domain.Contains 2 SH3 domains.

Gene Information

• Gene Name: GRAP2 GRB2-related adaptor protein 2 [ Homo sapiens ]
• Official Symbol: GRAP2
• Synonyms: GRAP2; GRB2-related adaptor protein 2; GRB2-related adapter protein 2; GADS; GRBLG; GrbX; Grf40; Mona
• Gene ID: 9402
• mRNA Refseq: NM_004810
• Protein Refseq: NP_004801
• MIM: 604518
• Uniprot ID: O75791
• Chromosome Location: 22q13.2
• Pathway: Adaptive Immune System, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: SH3/SH2 adaptor activity; protein binding