Recombinant Human GRK2 Protein (2-221 aa), His-tagged

• Cat.No.: GRK2-1177H
• Product Overview: Recombinant Human GRK2 Protein (2-221 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.

Specification

• Description: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of th. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 29.6 kDa
• Protein length: 2-221 aa
• AA Sequence: ADLEAVLADVSYLMAMEKSKATPAA RASKKILLPEPSIRSVMQKYLEDRG EVTFEKIFSQKLGYLLFRDFCLNHL EEARPLVEFYEEIKKYEKLETEEER VARSREIFDSYIMKELLACSHPFSK SATEHVQGHLGKKQVPPDLFQPYIE EICQNLRGDVFQKFIESDKFTRFCQ WKNVELNIHLTMNDFSVHRIIGRGG FGEVYGCRKADTGKMYAMKC
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens (human) ]
• Official Symbol: GRK2
• Synonyms: BARK1; ADRBK1; BETA-ARK1
• Gene ID: 156
• mRNA Refseq: NM_001619
• Protein Refseq: NP_001610
• UniProt ID: P25098