Recombinant Human GRK2 Protein (2-221 aa), His-tagged

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Recombinant Human GRK2 Protein (2-221 aa), His-tagged

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Cat.No. : GRK2-1177H
Product Overview : Recombinant Human GRK2 Protein (2-221 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Neuroscience. Protein Description: Partial.
Description : Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of th. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Source : E. coli
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 29.6 kDa
Protein length : 2-221 aa
AA Sequence : ADLEAVLADV SYLMAMEKSK ATPAARASKK ILLPEPSIRS VMQKYLEDRG EVTFEKIFSQ KLGYLLFRDF CLNHLEEARP LVEFYEEIKK YEKLETEEER VARSREIFDS YIMKELLACS HPFSKSATEH VQGHLGKKQV PPDLFQPYIE EICQNLRGDV FQKFIESDKF TRFCQWKNVE LNIHLTMNDF SVHRIIGRGG FGEVYGCRKA DTGKMYAMKC
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens (human) ]
Official Symbol : GRK2
Synonyms : BARK1; ADRBK1; BETA-ARK1;
Gene ID : 156
mRNA Refseq : NM_001619
Protein Refseq : NP_001610
UniProt ID : P25098

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