Human GRK2 Knockdown Cell Lysate

• Cat.No.: GRK2-349HKCL
• Product Overview: WB-validated GRK2 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 80 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg GRK2 KD HeLa cell lysate
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Endocytosis
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens (human) ]
• Official Symbol: GRK2
• Synonyms: GRK2; G protein-coupled receptor kinase 2; BARK1; ADRBK1; BETA-ARK1; beta-adrenergic receptor kinase 1; adrenergic beta receptor kinase 1; beta-ARK-1; EC 2.7.11.15
• Gene ID: 156
• mRNA Refseq: NM_001619
• Protein Refseq: NP_001610
• MIM: 109635
• UniProt ID: P25098