| Description : |
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
79.4 kDa |
| AA Sequence : |
MADLEAVLADVSYLMAMEKSKATPA ARASKKILLPEPSIRSVMQKYLEDR GEVTFEKIFSQKLGYLLFRDFCLNH LEEARPLVEFYEEIKKYEKLETEEE RVARSREIFDSYIMKELLACSHPFS KSATEHVQGHLGKKQVPPDLFQPYI EEICQNLRGDVFQKFIESDKFTRFC QWKNVELNIHLTMNDFSVHRIIGRG GFGEVYGCRKADTGKMYAMKCLDKK RIKMKQGETLALNERIMLSLVSTGD CPFIVCMSYAFHTPDKLSFILDLMN GGDLHYHLSQHGVFSEADMRFYAAE IILGLEHMHNRFVVYRDLKPANILL DEHGHVRISDLGLACDFSKKKPHAS VGTHGYMAPEVLQKGVAYDSSADWF SLGCMLFKLLRGHSPFRQHKTKDKH EIDRMTLTMAVELPDSFSPELRSLL EGLLQRDVNRRLGCLGRGAQEVKES PFFRSLDWQMVFLQKYPPPLIPPRG EVNAADAFDIGSFDEEDTKGIKLLD SDQELYRNFPLTISERWQQEVAETV FDTINAETDRLEARKKAKNKQLGHE EDYALGKDCIMHGYMSKMGNPFLTQ WQRRYFYLFPNRLEWRGEGEAPQSL LTMEEIQSVEETQIKERKCLLLKIR GGKQFILQCDSDPELVQWKKELRDA YREAQQLVQRVPKMKNKPRSPVVEL SKVPLVQRGSANGLSGPSGPTRTRR LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
