Recombinant Human GSDME Protein, MYC/DDK-tagged

• Cat.No.: GSDME-279H
• Product Overview: Recombinant Human GSDME, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.
• Molecular Mass: 54.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: GSDME gasdermin E [ Homo sapiens ]
• Official Symbol: DFNA5
• Synonyms: DFNA5; deafness, autosomal dominant 5; non-syndromic hearing impairment protein 5; ICERE 1; nonsyndromic hearing impairment protein; inversely correlated with estrogen receptor expression 1; ICERE-1
• Gene ID: 1687
• mRNA Refseq: NM_004403
• Protein Refseq: NP_001120925
• MIM: 608798
• UniProt ID: O60443