Recombinant Human GSK3A protein, His & GST-tagged

Cat.No. : GSK3A-634H
Product Overview : Recombinant Human GSK3A aa. (Gln115~Leu409 (Accession # P49840)) fused with N-terminal His & GST tag was produced in E. coli cells.
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Description : This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
Source : E. coli
Species : Human
Tag : His&GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 65.8kDa
Protein length : Gln115~Leu409 (Accession # P49840)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 7.3.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens (human) ]
Official Symbol : GSK3A
Synonyms : GSK3A; glycogen synthase kinase 3 alpha; glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A
Gene ID : 2931
mRNA Refseq : NM_019884.2
Protein Refseq : NP_063937.2
UniProt ID : P49840

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
08/12/2020

    Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

    09/18/2019

      This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

      04/10/2019

        the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.

        Q&As (5)

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        In what ways is GSK3A linked to diabetes? 09/27/2021

        GSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.

        Can GSK3A inhibitors have an impact on mood disorders? 11/16/2019

        Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.

        Are there GSK3A modulators being explored for anti-inflammatory therapies? 08/28/2019

        Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.

        How does GSK3A contribute to inflammatory conditions? 04/25/2017

        GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.

        Are there any clinical interventions targeting GSK3A for diabetes management? 04/02/2016

        Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.

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