Recombinant Human HGS, GST-tagged

• Cat.No.: HGS-13762H
• Product Overview: Recombinant Human HGS protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 186-387a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens ]
• Official Symbol: HGS
• Synonyms: HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; HRS; FLJ11421; FLJ39878
• Gene ID: 9146
• mRNA Refseq: NM_004712
• Protein Refseq: NP_004703
• MIM: 604375
• UniProt ID: O14964
• Chromosome Location: 17q25
• Pathway: CXCR4-mediated signaling events, organism-specific biosystem; Disease, organism-specific biosystem; EGFR downregulation, organism-specific biosystem; ESCRT-0 complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem
• Function: metal ion binding; protein binding; protein domain specific binding