Recombinant Human HSD17B3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: HSD17B3-1464H
• Product Overview: HSD17B3 MS Standard C13 and N15-labeled recombinant protein (NP_000188) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 34.5 kDa
• AA Sequence: MGDVLEQFFILTGLLVCLACLAKCV RFSRCVLLNYWKVLPKSFLRSMGQW AVITGAGDGIGKAYSFELAKRGLNV VLISRTLEKLEAIATEIERTTGRSV KIIQADFTKDDIYEHIKEKLAGLEI GILVNNVGMLPNLLPSHFLNAPDEI QSLIHCNITSVVKMTQLILKHMESR QKGLILNISSGIALFPWPLYSMYSA SKAFVCAFSKALQEEYKAKEVIIQV LTPYAVSTAMTKYLNTNVITKTADE FVKESLNYVTIGGETCGCLAHEILA GFLSLIPAWAFYSGAFQRLLLTHYV AYLKLNTKVRTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 [ Homo sapiens (human) ]
• Official Symbol: HSD17B3
• Synonyms: HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3; testosterone 17-beta-dehydrogenase 3; SDR12C2; short chain dehydrogenase/reductase family 12C; member 2; 17-beta-HSD3; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; testicular 17-beta-hydroxysteroid dehydrogenase; short chain dehydrogenase/reductase family 12C, member 2; EDH17B3
• Gene ID: 3293
• mRNA Refseq: NM_000197
• Protein Refseq: NP_000188
• MIM: 605573
• UniProt ID: P37058