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Recombinant Human ICOS Protein, Gly/Pro-tagged, FITC conjugated
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March 21, 2023 | Add to Quote |
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Cat.No. : | ICOS-390HF Optional Service: Optional requirements on this protein |
Product Overview : | FITC conjugated recombinant human ICOS (Met 1-Phe 141) was expressed in HEK293. |
Description : | Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness. |
Source : | HEK293 |
Species : | Human |
Tag : | Gly/Pro |
Form : | Lyophilized |
Protein length : | Met1-Phe141 |
N-terminal Sequence Analysis : | Glu 21 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | > 94 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with FITC via amines Excitation source: 488 nm spectral line, argon-ion laser Excitation Wavelength: 488 nm Emission Wavelength: 535 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 centigradeto -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. |
Shipping : | Shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | ICOS inducible T-cell co-stimulator [ Homo sapiens ] |
Official Symbol : | ICOS |
Synonyms : | ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850; |
Gene ID : | 29851 |
mRNA Refseq : | NM_012092 |
Protein Refseq : | NP_036224 |
MIM : | 604558 |
UniProt ID : | Q9Y6W8 |
◆ Recombinant Protein
ICOS-1015R | Recombinant Rhesus ICOS Protein (Met1-Lys140), HlgG1 Fc-tagged | +Inquiry |
ICOS-827M | Recombinant Mouse ICOS Protein (Met1-Leu144), RlgG Fc-tagged | +Inquiry |
ICOS-1611R | Recombinant Rhesus ICOS protein, hFc&Avi-tagged, Biotinylated | +Inquiry |
ICOS-175H | Recombinant Human ICOS Protein, Fc/His-tagged | +Inquiry |
Icos-1747M | Recombinant Mouse Inducible T-cell Co-stimulator | +Inquiry |
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◆ Lysates
ICOS-1195RCL | Recombinant Rat ICOS cell lysate | +Inquiry |
ICOS-2444HCL | Recombinant Human ICOS cell lysate | +Inquiry |
ICOS-1724MCL | Recombinant Mouse ICOS cell lysate | +Inquiry |
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