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Recombinant Human IL12RB2 Protein, Fc/His-tagged
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Cat.No. : | IL12RB2-9483H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human IL-12 R beta 2 protein (Lys24-Asn622) with Human IgG1 (Pro100-Lys330) and a 6-His tag at C-terminus was expressed in mouse myeloma cell line. |
Description : | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Fc/His |
Form : | Lyophilized |
Bio-activity : | Measured by its binding ability in a functional ELISA. When Recombinant Human IL‑12 is immobilized at 0.5 µg/mL, 100 µL/well, the concentration of Recombinant Human IL‑12 R beta 2 Fc that produces 50% of the optimal binding response is 0.015-0.09 µg/mL. |
Molecular Mass : | 95 kDa |
N-terminal Sequence Analysis : | Lys24 |
Endotoxin : | <0.10 EU per 1 µg of the protein by the LAL method. |
Purity : | > 95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. |
Reconstitution : | Reconstitute at 250 µg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. |
Binding Activity : |
![]() When Recombinant Human IL-12 is immobilized at 0.5 µg/mL, Recombinant Human IL-12 R beta 2 Fc Chimera binds with an ED50 of 0.015-0.09 µg/mL. |
SDS-PAGE : |
![]() 1 µg/lane of Recombinant Human IL‑12 R beta 2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silverstaining, showing bands at 112-133 kDa and 220-260 kDa, respectively. |
Gene Name : | IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ] |
Official Symbol : | IL12RB2 |
Synonyms : | IL12RB2; interleukin 12 receptor subunit beta 2; interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain |
Gene ID : | 3595 |
mRNA Refseq : | NM_001559 |
Protein Refseq : | NP_001550 |
MIM : | 601642 |
UniProt ID : | Q99665 |
◆ Recombinant Protein
IL12RB2-73H | Recombinant Human IL12RB2 protein, Fc-tagged | +Inquiry |
IL12RB2-214H | Recombinant Human IL12RB2 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL12RB2-3230H | Recombinant Human IL12RB2 Protein, His-tagged | +Inquiry |
IL12RB2-3885H | Recombinant Human IL12RB2 protein, His-tagged | +Inquiry |
IL12RB2-34C | Recombinant Cynomolgus IL12RB2 protein, mFc-tagged | +Inquiry |
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◆ Lysates
IL12RB2-2142MCL | Recombinant Mouse IL12RB2 cell lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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