Recombinant Human IL12RB2 Protein, Fc/His-tagged

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Recombinant Human IL12RB2 Protein, Fc/His-tagged

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Cat.No. : IL12RB2-9483H
Product Overview : Recombinant Human IL-12 R beta 2 protein (Lys24-Asn622) with Human IgG1 (Pro100-Lys330) and a 6-His tag at C-terminus was expressed in mouse myeloma cell line.
Description : The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
Source : Mouse myeloma cell line
Species : Human
Tag : Fc/His
Form : Lyophilized
Bio-activity : Measured by its binding ability in a functional ELISA. When Recombinant Human IL‑12 is immobilized at 0.5 µg/mL, 100 µL/well, the concentration of Recombinant Human IL‑12 R beta 2 Fc that produces 50% of the optimal binding response is 0.015-0.09 µg/mL.
Molecular Mass : 95 kDa
N-terminal Sequence Analysis : Lys24
Endotoxin : <0.10 EU per 1 µg of the protein by the LAL method.
Purity : > 95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.
Reconstitution : Reconstitute at 250 µg/mL in PBS.
Shipping : The product is shipped at ambient temperature.
Binding Activity :

When Recombinant Human IL-12 is immobilized at 0.5 µg/mL, Recombinant Human IL-12 R beta 2 Fc Chimera binds with an ED50 of 0.015-0.09 µg/mL.

SDS-PAGE :

1 µg/lane of Recombinant Human IL‑12 R beta 2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silverstaining, showing bands at 112-133 kDa and 220-260 kDa, respectively.

Gene Name : IL12RB2 interleukin 12 receptor subunit beta 2 [ Homo sapiens (human) ]
Official Symbol : IL12RB2
Synonyms : IL12RB2; interleukin 12 receptor subunit beta 2; interleukin-12 receptor subunit beta-2; IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain
Gene ID : 3595
mRNA Refseq : NM_001559
Protein Refseq : NP_001550
MIM : 601642
UniProt ID : Q99665

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