Recombinant Human IL13 protein, Fc-tagged
|Product Overview :||Recombinant Human IL13 (Gly21-Asn132) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
- Gene Information
- Related Products
|Description :||Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Gly21|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 38.8 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Gly21-Asn132|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>90% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name :||IL13|
|Official Symbol :||IL13|
|Synonyms :||IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13|
|Gene ID :||3596|
|mRNA Refseq :||NM_002188|
|Protein Refseq :||NP_002179|
|UniProt ID :||P35225|
|◆ Recombinant Protein|
|IL13-504H||Recombinant Human IL13 Protein, Fc-tagged||+Inquiry|
|Il13-087M||Active Recombinant Mouse Il13 Protein||+Inquiry|
|IL13-505H||Recombinant Human IL13 Protein||+Inquiry|
|IL13-2052R||Recombinant Rhesus Macaque IL13 Protein, His (Fc)-Avi-tagged||+Inquiry|
|IL13-1660R||Recombinant Rhesus monkey IL13 Protein, His-tagged||+Inquiry|
|IL13-1336MCL||Recombinant Mouse IL13 cell lysate||+Inquiry|
|IL13-001HCL||Recombinant Human IL13 cell lysate||+Inquiry|
|IL13-1894CCL||Recombinant Cynomolgus IL13 cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Flow cytometry quantifies IL13 receptor expression on cells.
Transgenic models illuminate IL13's in vivo functions.
ELISA quantifies IL13 secretion in cell cultures accurately.
siRNA knockdown uncovers IL13's specific cellular effects.
Co-immunoprecipitation identifies IL13 signaling partners.
Differential techniques distinguish IL13 and IL4 signaling pathways.
Reporter gene assays gauge IL13-driven transcription.
Microarray analysis profiles IL13-induced gene expression.
Experimental methods reveal IL13's impact on tissue remodeling.
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)Write a review
Effective in Th2 cell differentiation. -
Good for cytokine assays. -
High yield in expression. -
Ask a Question for All IL13 Products
Required fields are marked with *
My Review for All IL13 Products
Required fields are marked with *