Recombinant Human IL13 protein, Fc-tagged
| Cat.No. : | IL13-229H |
| Product Overview : | Recombinant Human IL13 (Gly21-Asn132) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
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| Description : | Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | human IgG1 Fc |
| Predicted N Terminal : | Gly21 |
| Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
| Molecular Mass : | The protein has a calculated MW of 38.8 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Protein length : | Gly21-Asn132 |
| Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
| Purity : | >90% as determined by SDS-PAGE. |
| Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Gene Name : | IL13 |
| Official Symbol : | IL13 |
| Synonyms : | IL13; interleukin 13; interleukin-13; allergic rhinitis; ALRH; BHR1; Bronchial hyperresponsiveness 1 (bronchial asthma); IL 13; MGC116786; MGC116788; MGC116789; P600; Bronchial hyperresponsiveness-1 (bronchial asthma); IL-13 |
| Gene ID : | 3596 |
| mRNA Refseq : | NM_002188 |
| Protein Refseq : | NP_002179 |
| MIM : | 147683 |
| UniProt ID : | P35225 |
Products Types
| ◆ Recombinant Protein | ||
| IL13-504H | Recombinant Human IL13 Protein, Fc-tagged | +Inquiry |
| Il13-087M | Active Recombinant Mouse Il13 Protein | +Inquiry |
| IL13-505H | Recombinant Human IL13 Protein | +Inquiry |
| IL13-2052R | Recombinant Rhesus Macaque IL13 Protein, His (Fc)-Avi-tagged | +Inquiry |
| IL13-1660R | Recombinant Rhesus monkey IL13 Protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| IL13-1336MCL | Recombinant Mouse IL13 cell lysate | +Inquiry |
| IL13-001HCL | Recombinant Human IL13 cell lysate | +Inquiry |
| IL13-1894CCL | Recombinant Cynomolgus IL13 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (10)
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How does flow cytometry help quantify IL13 receptor expression on different cell populations?
12/29/2022
Flow cytometry quantifies IL13 receptor expression on cells.
What are the benefits of using transgenic animal models to study IL13's in vivo functions?
07/05/2022
Transgenic models illuminate IL13's in vivo functions.
Could you explain the role of ELISA in quantifying IL13 secretion levels in cell cultures?
02/23/2022
ELISA quantifies IL13 secretion in cell cultures accurately.
How can siRNA knockdown experiments reveal IL13's effects on specific cellular processes?
06/13/2021
siRNA knockdown uncovers IL13's specific cellular effects.
How does co-immunoprecipitation identify interacting partners in IL13-mediated signaling complexes?
07/28/2019
Co-immunoprecipitation identifies IL13 signaling partners.
What techniques can differentiate IL13-mediated signaling pathways from IL4 pathways?
07/23/2019
Differential techniques distinguish IL13 and IL4 signaling pathways.
Could you elaborate on the use of reporter gene assays to assess IL13-driven transcriptional activity?
12/16/2018
Reporter gene assays gauge IL13-driven transcription.
Can you describe the applications of microarray analysis in profiling IL13-induced gene expression changes?
11/14/2018
Microarray analysis profiles IL13-induced gene expression.
What experimental methods determine the impact of IL13 on tissue remodeling processes?
08/04/2018
Experimental methods reveal IL13's impact on tissue remodeling.
How does site-directed mutagenesis help identify critical residues in IL13 receptor binding?
07/04/2018
Site-directed mutagenesis identifies key residues in IL13 receptor binding.
Customer Reviews (3)
Write a reviewReviews
11/29/2021
Effective in Th2 cell differentiation. -
04/22/2020
Good for cytokine assays. -
01/26/2019
High yield in expression. -
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