| Description : |
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
66.5 kDa |
| AA Sequence : |
MDYSFDTTAEDPWVRISDCIKNLFS PIMSENHGHMPLQPNASLNEEEGTQ GHPDGTPPKLDTANGTPKVYKSADS STVKKGPPVAPKPAWFRQSLKGLRN RASDPRGLPDPALSTQPAPASREHL GSHIRASSSSSSIRQRISSFETFGS SQLPDKGAQRLSLQPSSGEAAKPLG KHEEGRFSGLLGRGAAPTLVPQQPE QVLSSGSPAASEARDPGVSESPPPG RQPNQKTLPPGPDPLLRLLSTQAEE SQGPVLKMPSQRARSFPLTRSQSCE TKLLDEKTSKLYSISSQVSSAVMKS LLCLPSSISCAQTPCIPKEGASPTS SSNEDSAANGSAETSALDTGFSLNL SELREYTEGLTEAKEDDDGDHSSLQ SGQSVISLLSSEELKKLIEEVKVLD EATLKQLDGIHVTILHKEEGAGLGF SLAGGADLENKVITVHRVFPNGLAS QEGTIQKGNEVLSINGKSLKGTTHH DALAILRQAREPRQAVIVTRKLTPE AMPDLNSSTDSAASASAASDVSVES TAEATVCTVTLEKMSAGLGFSLEGG KGSLHGDKPLTINRIFKGAASEQSE TVQPGDEILQLGGTAMQGLTRFEAW NIIKALPDGPVTIVIRRKSLQSKET TAAGDSTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
