Recombinant Human IL20RA protein, His & GST-tagged

• Cat.No.: IL20RA-1325H
• Product Overview: Recombinant Human IL20RA aa. (Met269~Trp545 (Accession# Q9UHF4) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 61.1kDa
• Protein length: Met269~Trp545 (Accession# Q9UHF4)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >90%
• Characteristic: The isoelectric point is 4.1.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: IL20RA interleukin 20 receptor subunit alpha [ Homo sapiens (human) ]
• Official Symbol: IL20RA
• Synonyms: IL20RA; interleukin 20 receptor subunit alpha; CRF2-8; IL-20R1; IL-20RA; IL-20R-alpha; interleukin-20 receptor subunit alpha; class II cytokine receptor ZCYTOR7; cytokine receptor family 2 member 8; interleukin 20 receptor alpha subunit; interleukin 20 receptor, alpha; interleukin-20 receptor I
• Gene ID: 53832
• mRNA Refseq: NM_001278722.1
• Protein Refseq: NP_001265651.1
• UniProt ID: Q9UHF4

Reviews

07/12/2021

Good for signaling studies.

10/13/2017

High specificity.

10/03/2016

Effective in skin models.

Q&As

What is the impact of IL20RA on cytokine secretion?

IL20RA increases IL-17 and IL-22 production.

Does IL20RA expression correlate with disease severity in psoriasis?

IL20RA expression correlates with disease severity in psoriasis.

What is IL20RA's role in autoimmune diseases?

IL20RA is implicated in autoimmune diseases like psoriasis.

How does IL20RA modulate skin inflammation?

IL20RA modulates skin inflammation by activating keratinocytes.

How does IL20RA expression change in cancerous tissues?

IL20RA expression is upregulated in melanoma.

How does IL20RA influence the JAK-STAT signaling pathway?

IL20RA activates the JAK-STAT signaling pathway.

Does IL20RA interact with other interleukin receptors?

IL20RA interacts with IL-20 and IL-24 receptors.

How does IL20RA affect T-cell differentiation?

IL20RA induces Th17 cell differentiation.

Does IL20RA have a role in cell migration?

IL20RA promotes keratinocyte migration.

What post-translational modifications occur on IL20RA?

IL20RA undergoes phosphorylation.