Recombinant Rat Il22 protein
|Product Overview :||Recombinant Rat Il22 protein was expressed in Escherichia coli.|
- Gene Information
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|Description :||IL-22 is belonging to IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 and IL-22. It along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. Recombinant rat Interleukin-22 contains 146 amino acids and it has approximately 79 % and 92 % amino acid sequence identity with human and murine IL-22.|
|Form :||Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.|
|Bio-activity :||Fully biologically active when compared to standard. The ED50 as determined by inducing IL-10 secretion of human COLO 205 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 10⁶ IU/mg.|
|Molecular Mass :||Approximately16.6 kDa, a single non-glycosylated polypeptide chain containing 146 amino acids.|
|Protein length :||146|
|AA Sequence :||LPINSQCKLEAANFQQPYIVNRTFM LAKEASLADNNTDVRLIGEELFRGV KAKDQCYLMKQVLNFTLEDVLLPQS DRFQPYMQEVVPFLTKLSIHLSPCH ISGDDQNIQKNVRQLKETVQKLGES GEIKAIGELDLLFMSLRNACV|
|Endotoxin :||Less than 1 EU/μg of rRtIL-22 as determined by LAL method.|
|Purity :||>97% by SDS-PAGE and HPLC analysis.|
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.|
|Reconstitution :||We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.|
|Gene Name :||Il22|
|Official Symbol :||Il22|
|Synonyms :||Cytokine Zcyto 18, TIF|
|Gene ID :||500836|
|mRNA Refseq :||NM_001191988|
|Protein Refseq :||NP_001178917|
|UniProt ID :||Q198B4|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22 enhances gut epithelial repair mechanisms.
IL22 activates STAT3 to modulate downstream targets.
IL22 interacts synergistically with IL-17 during inflammation.
IL22 is involved in the pathogenesis of autoimmune diseases like Crohn's.
IL22 is implicated in metabolic syndrome by affecting insulin sensitivity.
IL22 expression is upregulated in psoriasis.
IL22 expression is upregulated during viral infections like Hepatitis C.
IL22 contributes to anti-tumor immunity by activating NK cells.
IL22 promotes Th22 cell differentiation.
IL22 polymorphisms affect its binding affinity and signaling.
Customer Reviews (3)Write a review
High specificity. -
Good for Th17 differentiation. -
Effective in gut repair assays. -
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