Recombinant Human IL23A Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | IL23A-638H |
Product Overview : | IL23A MS Standard C13 and N15-labeled recombinant protein (NP_057668) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 20.8 kDa |
AA Sequence : | MLGSRAVMLLLLLPWTAQGRAVPGG SSPAWTQCQQLSQKLCTLAWSAHPL VGHMDLREEGDEETTNDVPHIQCGD GCDPQGLRDNSQFCLQRIHQGLIFY EKLLGSDIFTGEPSLLPDSPVGQLH ASLLGLSQLLQPEGHHWETQQMPSL SPSQPWQRLLLRFKILRNLQAFVAV AARVFAHGAATLSPTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | IL23A interleukin 23 subunit alpha [ Homo sapiens (human) ] |
Official Symbol : | IL23A |
Synonyms : | IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388; |
Gene ID : | 51561 |
mRNA Refseq : | NM_016584 |
Protein Refseq : | NP_057668 |
MIM : | 605580 |
UniProt ID : | Q9NPF7 |
Products Types
◆ Recombinant Protein | ||
IL23A-2303H | Recombinant Human IL23A Protein, His-tagged | +Inquiry |
IL23A-244H | Active Recombinant Human IL23A Protein (Arg20-Pro189), N-His tagged, Animal-free, Carrier-free | +Inquiry |
Il23a-1927M | Recombinant Mouse Il23a Protein | +Inquiry |
IL23A-02H | Recombinant Human Active IL23A Protein, His-tagged | +Inquiry |
IL23A-179H | Recombinant Active Human IL23A Protein, His-tagged(N-ter) | +Inquiry |
◆ Lysates | ||
IL23A-5231HCL | Recombinant Human IL23A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewCoupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
Q&As (6)
Ask a questionPlease inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
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