| Cat.No. : |
Il23A-23H |
| Product Overview : |
Recombinant Human Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ), Subunit IL-23 alpha is fused with his-tag at the N-terminus and subunit IL-12 beta contains no tag was expressed in HEK293. |
| Description : |
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
| Molecular Mass : |
The protein has a calculated MW of 19.5 kDa (IL23A) & 34.7 kDa (IL12B). The protein migrates as 20 kDa (IL23A) & 40-45 kDa (IL12B) on a SDS-PAGE gel under reducing (R) condition due to glycosylation. |
| Protein length : |
Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ) |
| Endotoxin : |
Less than 1.0 EU per μg by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution. |
| Figure : |
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