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Recombinant Human Il23A&IL12B Protein, His-tagged
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Cat.No. : | Il23A-23H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ), Subunit IL-23 alpha is fused with his-tag at the N-terminus and subunit IL-12 beta contains no tag was expressed in HEK293. |
Description : | Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Molecular Mass : | The protein has a calculated MW of 19.5 kDa (IL23A) & 34.7 kDa (IL12B). The protein migrates as 20 kDa (IL23A) & 40-45 kDa (IL12B) on a SDS-PAGE gel under reducing (R) condition due to glycosylation. |
Protein length : | Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ) |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Figure : |
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Gene Name : | IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ] |
Official Symbol : | Il23A |
Synonyms : | IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388; |
Gene ID : | 51561 |
mRNA Refseq : | NM_016584 |
Protein Refseq : | NP_057668 |
MIM : | 605580 |
UniProt ID : | Q9NPF7 |
◆ Recombinant Protein
IL23A-32H | Recombinant Human IL23A Protein, Animal Free | +Inquiry |
Il23a-2305M | Recombinant Mouse Il23a Protein, His-tagged | +Inquiry |
IL23A-179H | Recombinant Active Human IL23A Protein, His-tagged(N-ter) | +Inquiry |
Il23a-1927M | Recombinant Mouse Il23a Protein | +Inquiry |
Il23a-3515M | Recombinant Mouse Il23a Protein | +Inquiry |
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◆ Lysates
IL23A-5231HCL | Recombinant Human IL23A 293 Cell Lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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