| Cat.No. : |
Il23A-23H
Optional Service: Optional requirements on this protein
|
| Product Overview : |
Recombinant Human Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ), Subunit IL-23 alpha is fused with his-tag at the N-terminus and subunit IL-12 beta contains no tag was expressed in HEK293. |
| Description : |
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
| Molecular Mass : |
The protein has a calculated MW of 19.5 kDa (IL23A) & 34.7 kDa (IL12B). The protein migrates as 20 kDa (IL23A) & 40-45 kDa (IL12B) on a SDS-PAGE gel under reducing (R) condition due to glycosylation. |
| Protein length : |
Il23A(Arg 20 - Pro 189)&IL12B(Ile 23 - Ser 328 ) |
| Endotoxin : |
Less than 1.0 EU per μg by the LAL method. |
| Purity : |
>95% as determined by SDS-PAGE. |
| Storage : |
For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution. |
| Figure : |
|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
