Recombinant Human IL2RB Protein, His-tagged

• Cat.No.: IL2RB-2310H
• Product Overview: Recombinant Human IL2RB Protein (Ala27-Thr240) with a N-His tag was expressed in E. coli.

Specification

• Description: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 26.2 kDa
  Accurate Molecular Mass: 28 kDa
• Protein length: Ala27-Thr240
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: IL2RB interleukin 2 receptor, beta [ Homo sapiens (human) ]
• Official Symbol: IL2RB
• Synonyms: IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75
• Gene ID: 3560
• mRNA Refseq: NM_000878
• Protein Refseq: NP_000869
• MIM: 146710
• UniProt ID: P14784

Reviews

09/07/2021

Immunogenicity is very weak and does not cause an immune response.

12/27/2019

Detection method is very sensitive and can detect trace amounts of protein.

08/15/2019

Preparation process is very simple and can be easily prepared.

Q&As

What is IL2RB and what are its clinical applications?

It is an artificial protein prepared by genetic engineering techniques that can mimic the natural IL-2R beta subunit and is used to explore how to treat cancer and autoimmune diseases by regulating the IL-2 signaling pathway.

What is the effect of IL2RB in the treatment of tumor?

There has shown good therapeutic effect in the treatment of some tumors (such as lung cancer, melanoma, etc.), but the specific efficacy varies with the patient's condition, treatment timing and other factors.

What is the therapeutic mechanism of IL2RB in clinical use?

This protein can simulate the natural IL-2R beta subunit and participate in the IL-2 signaling pathway, thereby enhancing the body's immunity.

What diseases is IL2RB associated with?

IL2RB is associated with a variety of cancers (such as gastric cancer, lung cancer, liver cancer, lymphoma, etc.) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus, etc.).

Can IL2RB be an alternative to traditional treatment?

IL2RB can be used as a new therapeutic method, but it does not mean that it can replace traditional therapeutic methods. In the course of specific treatment, different treatment methods should be considered according to the condition.

Does IL2RB have side effects?

IL2RB may produce some side effects, including fever, headache, nausea, vomiting, etc., but the incidence of different side effects is low.