Recombinant Human IL3RA Protein, His-Avi-tagged, Biotinylated

Cat.No. : IL3RA-156H
Product Overview : Biotinylated Human IL-3 R alpha, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305 (Accession # P26951-1).
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Description : Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.
Source : HEK293
Species : Human
Tag : His&Avi
Predicted N Terminal : Thr 19
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Molecular Mass : The protein has a calculated MW of 36.7 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE).
Protein length : Thr 19 - Arg 305
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL3RA interleukin 3 receptor, alpha (low affinity) [ Homo sapiens ]
Official Symbol : IL3RA
Synonyms : IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; CD123; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha
Gene ID : 3563
mRNA Refseq : NM_002183
Protein Refseq : NP_002174
MIM : 308385
UniProt ID : P26951

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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07/24/2022

    In special environment, good stability.

    05/25/2022

      Good crystallization property and good effect.

      06/29/2021

        Has the expected biological activity, such as enzyme activity and receptor binding activity, and so on.

        Q&As (6)

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        Can Il3ra be personalized? 08/01/2022

        The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.

        Does Il3ra have clinical application prospects? What are the prospects? 05/19/2022

        Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.

        What is the action mechanism of Il3ra? 04/24/2022

        Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.

        How is the clinical trial of Il3ra progressing? 09/16/2020

        Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.

        What is the specific effect of Il3ra on the immune system? 08/06/2019

        The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.

        Does Il3ra have side effects? 05/24/2019

        Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.

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