Recombinant Human IL4R Protein, GST-tagged
|Product Overview :||Human IL4R partial ORF ( NP_000409, 26 a.a. - 135 a.a.) recombinant protein with GST-tag at N-terminal.|
- Gene Information
- Related Products
|Description :||This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq|
|Source :||Wheat Germ|
|Molecular Mass :||37.84 kDa|
|AA Sequence :||MKVLQEPTCVSDYMSISTCEWKMNG PTNCSTELRLLYQLVFLLSEAHTCI PENNGGAGCVCHLLMDDVVSADNYT LDLWAGQQLLWKGSFKPSEHVKPRA PGNLTVHTNV|
|Applications :||Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
|Notes :||Best use within three months from the date of receipt of this protein.|
|Storage :||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.|
|Gene Name :||IL4R interleukin 4 receptor [ Homo sapiens ]|
|Official Symbol :||IL4R|
|Synonyms :||IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA;|
|Gene ID :||3566|
|mRNA Refseq :||NM_000418|
|Protein Refseq :||NP_000409|
|UniProt ID :||P24394|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
IL4R is a synthetic protein that mimics the IL-4 signaling pathway in nature and binds to the IL-4 receptor in cells, which can be used to study the IL-4 signaling pathway and related diseases.
Common IL4R production technologies include prokaryotic expression systems and mammalian cell expression systems.
This protein is used in tumor immunotherapy, which can promote anti-tumor immune response and enhance the anti-tumor effect of cytotoxic T lymphocytes.
It is mainly used in immunology, drug research and other fields. It is also widely used in vaccines, biotechnology, cancer treatment and so on.
IL4R is used to treat severe pheochromocytome-induced aerodoritis and was approved by the FDA as the first drug to treat this disease.
IL4R cannot generally be administered orally, and needs to be administered by injection or intravenous drip.
Customer Reviews (3)Write a review
Easy to attach to the surface of cells or materials. -
It has growth factor activity to promote cell growth and proliferation. -
In animals or humans caused by the prone production of antibodies. -
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