Recombinant Human Immunodeficiency Virus Type 1 Group M Subtype B VIF Protein (1-192 aa), His-sumostar-tagged
| Cat.No. : | VIF-2497H |
| Product Overview : | Recombinant Human Immunodeficiency Virus Type 1 Group M Subtype B (isolate BRU/LAI) (HIV-1) VIF Protein (1-192 aa) is produced by Yeast expression system. This protein is fused with a 6xHis-sumostar tag at the N-terminal. Protein Description: Full Length. |
- Specification
- Gene Information
- Related Products
| Description : | Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells. |
| Source : | Yeast |
| Species : | Human Immunodeficiency Virus Type 1 Group M Subtype B |
| Tag : | His-sumostar |
| Form : | Tris-based buffer,50% glycerol |
| Molecular Mass : | 38.5 kDa |
| Protein length : | 1-192 aa |
| AA Sequence : | MENRWQVMIVWQVDRMRIRTWKSLV KHHMYVSGKARGWFYRHHYESPHPR ISSEVHIPLGDARLVITTYWGLHTG ERDWHLGQGVSIEWRKKRYSTQVDP ELADQLIHLYYFDCFSDSAIRKALL GHIVSPRCEYQAGHNKVGSLQYLAL AALITPKKIKPPLPSVTKLTEDRWN KPQKTKGHRGSHTMNGH |
| Purity : | > 90% as determined by SDS-PAGE. |
| Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
| Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
| Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
| Gene Name : | vif Vif [ Human immunodeficiency virus 1 ] |
| Official Symbol : | VIF |
| Synonyms : | vif; |
| Gene ID : | 155459 |
| UniProt ID : | P69721 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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