Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged
Cat.No. : | IGF1-691H |
Product Overview : | Recombinant humanIGF1 contains 70 amino acids and a 13 amino acid Histidine-based tag. It hasa predicted molecular mass of 9.3 kDa and migrates with an apparent molecularmass of 12 kDa in SDS-PAGE. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IGF1-691H |
Description : | IGF-1 also known assomatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1has also been referred to as a "sulfation factor" and its effects weretermed "nonsuppressible insulin-like activity" (NSILA) in the1970s. IGF-1 is a hormone similar in molecular structure to insulin. It playsan important role in childhood growth and continues to have anabolic effectsin adults. A synthetic analog of IGF-1, mecasermin is used for the treatmentof growth failure. |
Source : | Hordeum vulgare(barley grain) |
Species : | Human |
Form : | Lyophilized from a0.2 um sterile filtered solution in 50 mM MES, pH 6.5+100 mM NaCI. |
Molecular Weight : | 12 kDa |
Purity : | >98% as determinedby SDS-PAGE analysis. Purified product carries no pyrogenic orpro-inflammatory contaminants, as assayed with monocyte activation test usingHuman 10-plex Cytokine Assay measuring IL-6, TNF-alpha and IL-1 betainduction. |
Endotoxin Level : | <0.005 ng/ug of IGF1 |
Biological Activity : | Bioactivity isassayed by measuring the dose dependent effect of human IGF1 on proliferationof FDC-P1 cells, mouse progenitor cells of granulocytes, monocytes andmacrophages. The ED50 for this effect is 10.0 ng/ml. |
Specific Activity : | 1x105U/mg |
Reconstitution : | Centrifuge vialprior to opening. Add sterile distilled water to the vial to fully solubilizethe protein to a concentration not less than 100 ug/ml. |
Storage : | Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C witha carrier protein (0.1%HSA or BSA) as a stabilizer for long term storage.Please note that the addition of any carrier protein into this product mayproduce unwanted endotoxin. This depends upon the particular application employed.Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | IGF1 |
Gene Name : | IGF1 insulin-like growth factor1 (somatomedin C) [ Homo sapiens ] |
Synonyms : | IGF1; insulin-likegrowth factor 1 (somatomedin C); insulin-likegrowth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080;OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083;OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I;insulin-like growth factor IA; insulin-like growth factor IB |
Gene ID : | 3479 |
mRNA Refseq : | NM_000618 |
Protein Refseq : | NP_000609 |
MIM : | 147440 |
UniProt ID : | P05019 |
Chromosome Location : | 12q23 |
Pathway : | Adipogenesis;Aldosterone-regulated sodium reabsorption; Apoptosis; Diabetes pathways; Dilatedcardiomyopathy; Endochondral Ossification; Focal Adhesion; Glioma;Hemostasis; Id Signaling Pathway; Oocyte meiosis; Pathways in cancer;Platelet activation; Prostate cancer; Synthesis |
Function : | growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; integrin binding; protein binding |
Products Types
◆ Recombinant Protein | ||
IGF1-22H | Recombinant Human/Bovine/Porcine IGF1 Protein | +Inquiry |
Igf1-081M | Recombinant Mouse Igf1 Protein, MYC/DDK-tagged | +Inquiry |
IGF1-085I | Active Recombinant Human LR3IGF1 Protein (83 aa) | +Inquiry |
Igf1-374I | Active Recombinant Rat Igf1 Protein (71 aa) | +Inquiry |
IGF1-210P | Recombinant Pig IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
IGF1-5268HCL | Recombinant Human IGF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket