Recombinant Human Interleukin 4 Receptor
Cat.No. : | IL4R-586H |
Product Overview : | This recombinant human sIL-4R alpha is a 23.7 kDa protein containing 207 amino acid residues consisting of only the extracellular domain of the IL-4R alpha. It is produced inHEK 293 cells. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL4R-586H |
Description : | Human IL-4 exerts its biological effects via signaling through its receptor system, IL-4R. There are two types of the IL-4 receptor complexes, the type I receptor consisting of the IL-4R alpha and the common gamma chain, yc and the type II receptor consisting of IL-4R alpha and the IL-13R alpha. The IL-4R alpha chain contains an extracellular domain of 207 amino acids, a transmembrane domain of 24 amino acids, and an intracellular domain of 569 amino acids. |
Source : | HEK 293 cells. |
Amino Acid Sequence : | MKVLQEPTCV SDYMSISTCE WKMNGPTNCS TELRLLYQLV FLLSEAHTCI PENNGGAGCV CHLLMDDVVS ADNYTLDLWA GQQLLWKGSF KPSEHVKPRA PGNLTVHTNV SDTLLLTWSN PYPPDNYLYN HLTYAVNIWS ENDPADFRIY NVTYLEPSLR IAASTLKSGI SYRARVRAWA QCYNTTWSEW SPSTKWHNSY REPFEQH. |
Note : | If this material is not to be used for coating or labeling or other applications requiring carrier free material), the addition of 0.1% BSA to dilution buffers or dilution in sterile culture media is recommended to enhance stability and minimize absorption to vial. |
Supplied : | The sterile filtered solution was lyophilized from 1 x PBS, pH 7.2. |
Purity : | Greater than 97% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
Reconstitution : | We recommend a quick spin followed by reconstitution in 1 x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/ml. Allow to set at least 10 minutes. Rotate and/or vortex to mix. Centrifuge for 1-2 minutes at 1000 rpm to concentrate solution in bottom of vial. |
Reactivity : | The ED50as determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is < 5.0 ng/ml (in the presence of 0.5 ng/ml IL-4), corresponding to a specific activity of > 2 x105 units/mg. |
Storage : | The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20℃. Reconstituted IL-4R should be stored in working aliquots at -20℃. Avoid frequent freeze thaw cycles. |
Gene Name : | IL4R interleukin 4 receptor [ Homo sapiens ] |
Synonyms : | IL4R; interleukin 4 receptor; CD124; IL4RA; interleukin 4 receptor alpha chain; OTTHUMP00000122506; interleukin-4 receptor alpha chain;CD_antigen;IL-4R-alpha;Soluble interleukin-4 receptor alpha chain; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP |
Gene ID : | 3566 |
mRNA Refseq : | NM_000418 |
Protein Refseq : | NP_000409 |
MIM : | 147781 |
UniProt ID : | P24394 |
Chromosome Location : | 16p12.1-p11.2 |
Pathway : | Cytokine-cytokine receptor interaction; Endocytosis; Hematopoietic cell lineage; Jak-STAT signaling pathway |
Function : | interleukin-4 receptor activity; receptor activity; protein binding; receptor signaling protein activity |
Products Types
◆ Recombinant Protein | ||
IL4R-01H | Active Recombinant Human IL4R Protein | +Inquiry |
IL4R-329C | Recombinant Cynomolgus monkey IL4R Protein, His-tagged | +Inquiry |
IL4R-331H | Recombinant Human IL4R Protein, His-tagged | +Inquiry |
IL4R-330C | Recombinant Cynomolgus monkey IL4R Protein, Fc-tagged | +Inquiry |
IL4R-2388P | Recombinant Pig IL4R Protein (33-240 aa), His-tagged | +Inquiry |
◆ Lysates | ||
IL4R-1051RCL | Recombinant Rat IL4R cell lysate | +Inquiry |
IL4R-2719HCL | Recombinant Human IL4R cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket