Recombinant Human JAK2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: JAK2-3372H
• Product Overview: JAK2 MS Standard C13 and N15-labeled recombinant protein (NP_004963) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 130.5 kDa
• AA Sequence: MGMACLTMTEMEGTSTSSIYQNGDI SGNANSMKQIDPVLQVYLYHSLGKS EADYLTFPSGEYVAEEICIAASKAC GITPVYHNMFALMSETERIWYPPNH VFHIDESTRHNVLYRIRFYFPRWYC SGSNRAYRHGISRGAEAPLLDDFVM SYLFAQWRHDFVHGWIKVPVTHETQ EECLGMAVLDMMRIAKENDQTPLAI YNSISYKTFLPKCIRAKIQDYHILT RKRIRYRFRRFIQQFSQCKATARNL KLKYLINLETLQSAFYTEKFEVKEP GSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIID VSIKQANQEGSNESRVVTIHKQDGK NLEIELSSLREALSFVSLIDGYYRL TADAHHYLCKEVAPPAVLENIQSNC HGPISMDFAISKLKKAGNQTGLYVL RCSPKDFNKYFLTFAVERENVIEYK HCLITKNENEEYNLSGTKKNFSSLK DLLNCYQMETVRSDNIIFQFTKCCP PKPKDKSNLLVFRTNGVSDVPTSPT LQRPTHMNQMVFHKIRNEDLIFNES LGQGTFTKIFKGVRREVGDYGQLHE TEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGDENILV QEFVKFGSLDTYLKKNKNCINILWK LEVAKQLAWAMHFLEENTLIHGNVC AKNILLIREEDRKTGNPPFIKLSDP GISITVLPKDILQERIPWVPPECIE NPKNLNLATDKWSFGTTLWEICSGG DKPLSALDSQRKLQFYEDRHQLPAP KWAELANLINNCMDYEPDFRPSFRA IIRDLNSLFTPDYELLTENDMLPNM RIGALGFSGAFEDRDPTQFEERHLK FLQQLGKGNFGSVEMCRYDPLQDNT GEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNL KLIMEYLPYGSLRDYLQKHKERIDH IKLLQYTSQICKGMEYLGTKRYIHR DLATRNILVENENRVKIGDFGLTKV LPQDKEYYKVKEPGESPIFWYAPES LTESKFSVASDVWSFGVVLYELFTY IEKSKSPPAEFMRMIGNDKQGQMIV FHLIELLKNNGRLPRPDGCPDEIYM IMTECWNNNVNQRPSFRDLALRVDQ IRDNMAGTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: JAK2 Janus kinase 2 [ Homo sapiens (human) ]
• Official Symbol: JAK2
• Synonyms: JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3
• Gene ID: 3717
• mRNA Refseq: NM_004972
• Protein Refseq: NP_004963
• MIM: 147796
• UniProt ID: O60674