| Description : |
Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408). |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His-GST |
| Molecular Mass : |
48.8 kDa |
| Protein length : |
1-181 |
| Purity : |
>90% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB). |
| Applications : |
ELISA, Western Blot, Antibody Production, Protein array |
| Quality Control Test : |
10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry. |
| Storage : |
Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade. |
| Expiry : |
12 months from the date of purchase, if it is properly stored. |
| Storage Buffer : |
Phosphate-Buffered Saline (PBS), pH 7.4. No preservatives added. |
| Shipping : |
Dry Ice |
