Recombinant Human K(Lysine) Acetyltransferase 7, GST-tagged

• Cat.No.: KAT7-1601H
• Product Overview: Recombinant full-length human KAT7 (MYST2) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: KAT7 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein which play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT7 acts as a transcriptional inhibitor and inhibited AR-mediated transactivation of reporter constructs in CV-1 and PC-3 cells. KAT7 is part of a multisubunit complex that can acetylate histones H3 and H4.
• Applications: Western Blot
• Molecular Weight: 110 kDa
• Expression System: Sf9 insect cells using baculovirus.
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol.
• Purity: > 85 %
• Concentration: 0.1 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Androgen Receptor Signaling Pathway; Regulation of Androgen receptor activity

Gene Information

• Gene Name: KAT7 K(lysine) acetyltransferase 7 [ Homo sapiens ]
• Official Symbol: KAT7
• Synonyms: KAT7; HBO1; HBOA; MYST2; MYST histone acetyltransferase 2; Histone acetyltransferase binding to ORC1; MYST-2; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; OTTHUMP00000220716; OTTHUMP00000220718; histone acetyltransferase MYST2; EC2.3.1.48
• Gene ID: 11143
• mRNA Refseq: NM_007067
• Protein Refseq: NP_008998
• MIM: 609880
• UniProt ID: O95251
• Chromosome Location: 17q21.32
• Function: histone acetyltransferase activity; metal ion binding; protein binding; sequence-specific DNA binding transcription factor activity; transferase activity, transferring acyl groups other than aminoacyl groups; zinc ion binding