Recombinant Human KAT2B , GST-tagged
Cat.No. : | KAT2B-6953H |
Product Overview : | Recombinant human KAT2B (PCAF) (431-end; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | KAT2B (also known as PCAF) is a transcription cofactor with a histone acetyltransferase (HAT) activity. KAT2B protein associates with p300/CBP which is a large nuclear protein that bind to many sequence-specific factors that are involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. KAT2B has histone acetyl transferase activity with core histones and nucleosome core particles indicating that KAT2B plays a direct role in transcriptional regulation. PCAF functions as a coordinating factor in the regulation of HIF1A-mediated apoptosis and p53-dependent cell cycle progression. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~70 kDa |
Protein length : | 431 aa-end; contains the catalytic domain |
Purity : | >95% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1 μg/μ |
Gene Name : | KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ] |
Official Symbol : | KAT2B |
Synonyms : | KAT2B; K(lysine) acetyltransferase 2B; p300/CBP associated factor , PCAF; histone acetyltransferase KAT2B; GCN5; GCN5L; P/CAF; histone acetylase PCAF; CREBBP-associated factor; p300/CBP-associated factor; lysine acetyltransferase 2B; histone acetyltransferase PCAF; P; CAF; PCAF; |
Gene ID : | 8850 |
mRNA Refseq : | NM_003884 |
Protein Refseq : | NP_003875 |
MIM : | 602303 |
UniProt ID : | Q92831 |
Chromosome Location : | 3p24 |
Pathway : | Androgen Receptor Signaling Pathway, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; |
Function : | acetyltransferase activity; cyclin-dependent protein kinase inhibitor activity; histone acetyltransferase activity; histone deacetylase binding; lysine N-acetyltransferase activity; lysine N-acetyltransferase activity; protein binding; protein kinase binding; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transferase activity, transferring acyl groups; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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