Recombinant Human KAT2B protein, MYC/DDK-tagged

• Cat.No.: KAT2B-126H
• Product Overview: Recombinant Human KAT2B fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 92.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ]
• Official Symbol: KAT2B
• Synonyms: KAT2B; K(lysine) acetyltransferase 2B; p300/CBP associated factor , PCAF; histone acetyltransferase KAT2B; GCN5; GCN5L; P/CAF; histone acetylase PCAF; CREBBP-associated factor; p300/CBP-associated factor; lysine acetyltransferase 2B; histone acetyltransferase PCAF; P; CAF; PCAF
• Gene ID: 8850
• mRNA Refseq: NM_003884
• Protein Refseq: NP_003875
• MIM: 602303
• UniProt ID: Q92831
• Chromosome Location: 3p24
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem
• Function: acetyltransferase activity; cyclin-dependent protein kinase inhibitor activity; histone acetyltransferase activity; histone deacetylase binding; lysine N-acetyltransferase activity; lysine N-acetyltransferase activity; protein binding; protein kinase binding; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transferase activity, transferring acyl groups