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Active Recombinant Human KDM2A protein, FLAG-Avi-tagged

Cat.No. : KDM2A-45H
Product Overview : Recombinant Human KDM2A(a.a: 2-700) fused with FLAG-Avi tag at N-terminal was expressed in Insect cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
Source : Insect cells
Species : Human
Tag : FLAG-Avi
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 80 μg/ml FLAG peptide
Bio-activity : 0.01 pmole/min/μg
Molecular Mass : 82 kDa
Purity : >80%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Notes : Avoid freeze/thaw cycles. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%).
Storage : >6 months at –80 centigrade.
Gene Name : KDM2A lysine (K)-specific demethylase 2A [ Homo sapiens ]
Official Symbol : KDM2A
Synonyms : KDM2A; lysine (K)-specific demethylase 2A; F box and leucine rich repeat protein 11 , FBXL11; lysine-specific demethylase 2A; CXXC8; DKFZP434M1735; F box protein FBL11; FBL7; FBL11; FLJ00115; JHDM1A; jumonji C domain containing histone demethylase 1A; KIAA1004; LILINA; F-box/LRR-repeat protein 11; CXXC-type zinc finger protein 8; [Histone-H3]-lysine-36 demethylase 1A; F-box and leucine-rich repeat protein 11; jumonji C domain-containing histone demethylase 1A; jmjC domain-containing histone demethylation protein 1A; FBXL11; FLJ46431; DKFZp434M1735;
Gene ID : 22992
mRNA Refseq : NM_012308
Protein Refseq : NP_036440
MIM : 605657
UniProt ID : Q9Y2K7
Chromosome Location : 11q13.1
Function : DNA binding; histone demethylase activity (H3-K36 specific); metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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