Recombinant Human KDR, Fc-tagged

Cat.No. : KDR-31716TH
Product Overview : Recombinant fragment: human soluble Vascular Endothelial Growth Factor Receptor 2 (sVEGFR2) was fused with the Fc part of human IgG1 and expressed in Insect cells. The recombinantsVEGFR2/Fc is a disulfide-linked homodimeric protein, M.Wt of themonomer is
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Description : Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Conjugation : Fc
Form : Lyophilised:sVEGFR 2/Fc should be reconstituted in PBS or medium to a concentration not lower than 50 μg/ml.
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 7 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
Gene Name : KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ]
Official Symbol : KDR
Synonyms : KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2;
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
Uniprot ID : P35968
Chromosome Location : 4q11-q12
Pathway : Angiogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem;
Function : ATP binding; Hsp90 protein binding; growth factor binding; integrin binding; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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