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Recombinant Human MTHFD2 protein, his-tagged

Cat.No. : MTHFD2-22H
Product Overview : Recombinant Human MTHFD2 Protein was expressed in E.coli with His-tag.
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Source : E.coli
Species : Human
Tag : His
Form : Liquid
Molecular Mass : 37.2 kDa
AA Sequence : MGSSHHHHHHSSGLVPRGSHMGSLA AVRNEAVVISGRKLAQQIKQEVRQE VEEWVASGNKRPHLSVILVGENPAS HSYVLNKTRAAAVVGINSETIMKPA SISEEELLNLINKLNNDDNVDGLLV QLPLPEHIDERRICNAVSPDKDVDG FHVINVGRMCLDQYSMLPATPWGVW EIIKRTGIPTLGKNVVVAGRSKNVG MPIAMLLHTDGAHERPGGDATVTIS HRYTPKEQLKKHTILADIVISAAGI PNLITADMIKEGAAVIDVGINRVHD PVTAKPKLVGDVDFEGVRQKAGYIT PVPGGVGPMTVAMLMKNTIIAAKKV LRLEEREVLKSKELGVATN
Purity : > 95 % by SDS-PAGE
Storage : Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/mL (determined by Bradford assay)
Storage Buffer : In Phosphate buffered saline (pH7.4) containing 20% glycerol, 1mM DTT
Gene Name : MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [ Homo sapiens (human) ]
Official Symbol : MTHFD2
Synonyms : MTHFD2; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase; NMDMC; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; EC 1.5.1.15; EC 3.5.4.9
Gene ID : 10797
mRNA Refseq : NM_006636
Protein Refseq : NP_006627
MIM : 604887
UniProt ID : P13995

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MTHFD2 impact folate metabolism? 02/07/2021

MTHFD2 is involved in the mitochondrial folate pathway, influencing the synthesis of nucleotides and methionine.

Are there any ongoing clinical trials targeting MTHFD2? 10/07/2020

Some clinical trials are exploring the efficacy of MTHFD2 inhibitors in cancer treatment.

In what conditions is the expression of MTHFD2 altered? 06/29/2018

MTHFD2 expression is often dysregulated in cancer and other metabolic disorders.

Are there specific inhibitors or drugs targeting MTHFD2? 02/08/2018

Research is ongoing to develop inhibitors that selectively target MTHFD2, showing promise for cancer treatment.

Can MTHFD2 be used as a diagnostic marker for certain diseases? 09/17/2017

Elevated MTHFD2 levels have been observed in certain cancers, suggesting its potential as a diagnostic marker.

Customer Reviews (3)

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11/15/2020

    It can also be employed in various molecular biology techniques, such as Western blotting, immunoprecipitation, or protein-protein interaction studies.

    02/01/2020

      Its versatility allows researchers to explore MTHFD2's involvement in diverse biological processes and fully uncover its functional role.

      02/17/2016

        the MTHFD2 protein's high quality, dependable performance, and comprehensive technical support make it an excellent choice for researchers seeking to investigate angiopoietin-related biology and unravel the complexities of vascular development and pathogenesis.

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