Active Recombinant Human KMT2A protein, GST-tagged

• Cat.No.: KMT2A-189H
• Product Overview: Recombinant Human KMT2A(3738-end) fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 600 nmol/min/mg
• Molecular Mass: 52 kDa
• Protein length: 3738-end
• Purity: >90%
• Applications: Methyltransferase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: KMT2A lysine methyltransferase 2A [ Homo sapiens ]
• Official Symbol: KMT2A
• Synonyms: HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/h
• Gene ID: 4297
• mRNA Refseq: NM_005933
• Protein Refseq: NP_005924
• MIM: 159555
• UniProt ID: Q03164
• Chromosome Location: 11q23.3
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Histone Modifications, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
• Function: AT DNA binding; chromatin binding; histone-lysine N-methyltransferase activity