"KMT2A" Related Products

Recombinant Human KMT2A protein, GST-tagged, Active

Cat.No.: KMT2A-189H
Product Overview: Recombinant Human KMT2A(3738-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Histone-lysine N-methyltransferase 2A also known as mixed-lineage leukemia 1 (MLL1) methylates histone H3 on lysine 4 (H3K4) to promote genome accessibility and transcription. Dysregulation or mutation of the KMT2 family have been found in human cancer, exemplified by the initial discovery of KMT2A rearrangements as causes of MLL.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 600 nmol/min/mg
Molecular Mass: 52 kDa
Protein length: 3738-end
Purity: >90%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: KMT2A lysine methyltransferase 2A [ Homo sapiens ]
Official Symbol: KMT2A
Synonyms: HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/h
Gene ID: 4297
mRNA Refseq: NM_005933
Protein Refseq: NP_005924
MIM: 159555
UniProt ID: Q03164
Chromosome Location: 11q23.3
Pathway: Chromatin modifying enzymes, organism-specific biosystem; Histone Modifications, organism-specific biosystem; PKMTs methylate histone lysines, organism-specific biosystem
Function: AT DNA binding; chromatin binding; histone-lysine N-methyltransferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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