Recombinant Human LBP (I465F) Protein, His-tagged

• Cat.No.: LBP-11116H
• Product Overview: Human Lipopolysaccharide-binding (I465F) Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Val 481 (Accession # P18428-1 (I465F)). This protein carries a polyhistidine tag at the C-terminus. Predicted N-terminus: Ala 26

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 26-481 aa
• Description: Lipopolysaccharide-binding protein (LBP), a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao, LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
• Molecular Mass: The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU/μg by the LAL method/rFC method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: LBP lipopolysaccharide binding protein [ Homo sapiens (human) ]
• Official Symbol: LBP
• Synonyms: LBP; lipopolysaccharide binding protein; lipopolysaccharide-binding protein; BPI fold containing family D; member 2; BPIFD2; LPS-binding protein; BPI fold containing family D, member 2; MGC22233
• Gene ID: 3929
• mRNA Refseq: NM_004139
• Protein Refseq: NP_004130
• MIM: 151990
• UniProt ID: P18428