| Description : |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
95.38 kDa |
| AA Sequence : |
MGPWGWKLRWTVALLLAAAGTAVGD RCERNEFQCQDGKCISYKWVCDGSA ECQDGSDESQETCLSVTCKSGDFSC GGRVNRCIPQFWRCDGQVDCDNGSD EQGCPPKTCSQDEFRCHDGKCISRQ FVCDSDRDCLDGSDEASCPVLTCGP ASFQCNSSTCIPQLWACDNDPDCED GSDEWPQRCRGLYVFQGDSSPCSAF EFHCLSGECIHSSWRCDGGPDCKDK SDEENCAVATCRPDEFQCSDGNCIH GSRQCDREYDCKDMSDEVGCVNVTL CEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGC SHVCNDLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGGY KCQCEEGFQLDPHTKACKAVGSIAY LFFTNRHEVRKMTLDRSEYTSLIPN LRNVVALDTEVASNRIYWSDLSQRM ICSTQLDRAHGVSSYDTVISRDIQA PDGLAVDWIHSNIYWTDSVLGTVSV ADTKGVKRKTLFRENGSKPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIYSLVTENIQWPNGITLDLLSGRL YWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIIN EAIFSANRLTGSDVNLLAENLLSPE DMVLFHNLTQPRGVNWCERTTLSNG GCQYLCLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETS TVRLKVSSTAVRTQHTTTRPVPDTS RLPGATPGLTTVEIVTMSHQALGDV AGRGNEKKPSSVRALSIVLPIVLLV FLCLGVFLLWKNWRLKNINSINFDN PVYQKTTEDEVHICHNQDGYSYPSR QMVSLEDDVATRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
