Recombinant Human LRP5 protein, Mouse IgG Fc-tagged


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Recombinant Human LRP5 protein, Mouse IgG Fc-tagged

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Cat.No. : LRP5-284H
Product Overview : Recombinant Human LRP5 (Glu644-Gln1263) protein was fused to mouse IgG2a Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
Source : HEK293
Species : Human
Tag : Mouse IgG Fc
Predicted N Terminal : Glu644
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 96.6 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Glu644-Gln1263
Endotoxin : Less than 0.1 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of LRP5-284H :

Human LRP-5, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA of LRP5-284H :

Immobilized Biotinylated Human Dkk-1, Fc,Avitag at 5 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate, can bind Human LRP-5, Mouse IgG2a Fc Tag with a linear range of 0.5-16 ng/mL (QC tested).

Bioactivity-ELISA :

Immobilized Human Dkk-1, His Tag at 5 μg/mL (100 μL/well) can bind Human LRP-5, Mouse IgG2a Fc Tag with a linear range of 0.01-0.313 μg/mL (Routinely tested).

Gene Name : LRP5
Official Symbol : LRP5
Synonyms : LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1, LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS; LRP-5; low density lipoprotein receptor-related protein 7; EVR1; EVR4; LRP7; OPPG; OPTA1; VBCH2
Gene ID : 4041
mRNA Refseq : NM_002335
Protein Refseq : NP_002326
MIM : 603506
UniProt ID : O75197

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