| Description : |
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
107.9 kDa |
| AA Sequence : |
MVLPTCPMAEFALPRHSAVMERLRR RIELCRRHHSTCEARYEAVSPERLE LERQHTFALHQRCIQAKAKRAGKHR QPPAATAPAPAAPAPRLDAADGPEH GRPATHLHDTVKRNLDSATSPQNGD QQNGYGDLFPGHKKTRREAPLGVAI SSNGLPPASPLGQSDKPSGADALQS SGKHSLGLDSLNKKRLADSSLHLNG GSNPSESFPLSLNKELKQEPVEDLP CMITGTVGSISQSNLMPDLNLNEQE WKELIEELNRSVPDEDMKDLFNEDF EEKKDPESSGSATQTPLAQDINIKT EFSPAAFEQEQLGSPQVRAGSAGQT FLGPSSAPVSTDSPSLGGSQTLFHT SGQPRADNPSPNLMPASAQAQNAQR ALAGVVLPSQGPGGASELSSAHQLQ QIAAKQKREQMLQNPQQATPAPAPG QMSTWQQTGPSHSSLDVPYPMEKPA SPSSYKQDFTNSKLLMMPSVNKSSP RPGGPYLQPSHVNLLSHQPPSNLNQ NSANNQGSVLDYGNTKPLSHYKADC GQGSPGSGQSKPALMAYLPQQLSHI SHEQNSLFLMKPKPGNMPFRSLVPP GQEQNPSSVPVQAQATSVGTQPPAV SVASSHNSSPYLSSQQQAAVMKQHQ LLLDQQKQREQQQKHLQQQQFLQRQ QHLLAEQEKQQFQRHLTRPPPQYQD PTQGSFPQQVGQFTGSSAAVPGMNT LGPSNSSCPRVFPQAGNLMPMGPGH ASVSSLPTNSGQQDRGVAQFPGSQN MPQSSLYGMASGITQIVAQPPPQAT NGHAHIPRQTNVGQNTSVSAAYGQN SLGSSGLSQQHNKGTLNPGLTKPPV PRVSPAMGGQNSSWQHQGMPNLSGQ TPGNSNVSPFTAASSFHMQQQAHLK MSSPQFSQAVPNRPMAPMSSAAAVG SLLPPVSAQQRTSAPAPAPPPTAPQ QGLPGLSPAGPELGAFSQSPASQMG GRAGLHCTQAYPVRTAGQELPFAYS GQPGGSGLSSVAGHTDLIDSLLKNR TSEEWMSDLDDLLGSQTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
