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Active Recombinant Human MAPT Protein

Cat.No. : MAPT-516H
Product Overview : Active Human Recombinant Tau (K18), P301L mutant Protein (Pre-formed Fibrils) without tag was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Source : E. coli
Species : Human
Bio-activity : Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
Molecular Mass : ~15.1 kDa
AA Sequence : SRLQTAPVPMPDLKNVKSKIGSTEN LKHQPGGGKVQIINKKLDLSNVQSK CGSKDNIKHVLGGGSVQIVYKPVDL SKVTSKCGSLGNIHHKPGGGQVEVK SEKLDFKDRVQSKIGSLDNITHVPG GGNKKIETHKLTFRE
Purity : >95%
Applications : WB, SDS-PAGE, In vivo assay, In vitro assay
Usage : Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Storage : At -80 centigrade.
Storage Buffer : 10 mM HEPES, 100 mM NaCl pH 7.4
Gene Name : MAPT microtubule associated protein tau [ Homo sapiens (human) ]
Official Symbol : MAPT
Synonyms : MAPT; microtubule associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103. microtubule-associated protein tau; G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103
Gene ID : 4137
mRNA Refseq : NM_016841
Protein Refseq : NP_058525
MIM : 157140
UniProt ID : P10636

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to assess the degree of abnormal aggregation of MAPT protein? 12/13/2019

The degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.

What is the relationship between MAPT protein and nerve cytoskeleton? 11/30/2019

The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.

What are the interactions of the MAPT protein with other proteins in the nervous system? 10/24/2019

MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.

Is there a mechanism that regulates the expression of MAPT protein? 10/21/2019

Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.

What are the future directions for MAPT protein research? 07/06/2019

Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.

How about the applications of MAPT protein in clinical diagnosis? 07/05/2019

The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.

Customer Reviews (3)

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Reviews
07/22/2022

    Western-blot experiments using MAPT as a target have shown highly reproducible results.

    08/08/2020

      This stability of MAPT is very good and can maintain its original properties even after multiple uses.

      09/15/2019

        MAPT's purity and consistency make it a top choice for Western-blot experiments.

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