Recombinant Human MATK Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human MATK Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : MATK-6365H
Product Overview : MATK MS Standard C13 and N15-labeled recombinant protein (NP_647611) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56.5 kDa
AA Sequence : MAGRGSLVSW RAFHGCDSAE ELPRVSPRFL RAWHPPPVSA RMPTRRWAPG TQCITKCEHT RPKPGELAFR KGDVVTILEA CENKSWYRVK HHTSGQEGLL AAGALREREA LSADPKLSLM PWFHGKISGQ EAVQQLQPPE DGLFLVRESA RHPGDYVLCV SFGRDVIHYR VLHRDGHLTI DEAVFFCNLM DMVEHYSKDK GAICTKLVRP KRKHGTKSAE EELARAGWLL NLQHLTLGAQ IGEGEFGAVL QGEYLGQKVA VKNIKCDVTA QAFLDETAVM TKMQHENLVR LLGVILHQGL YIVMEHVSKG NLVNFLRTRG RALVNTAQLL QFSLHVAEGM EYLESKKLVH RDLAARNILV SEDLVAKVSD FGLAKAERKG LDSSRLPVKW TAPEALKHGK FTSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG YRMEPPEGCP GPVHVLMSSC WEAEPARRPP FRKLAEKLAR ELRSAGAPAS VSGQDADGST SPRSQEPTRT RPLEQKLISE EDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : MATK megakaryocyte-associated tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : MATK
Synonyms : MATK; megakaryocyte-associated tyrosine kinase; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK; megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; Csk-homologous kinase; Csk-type protein tyrosine kinase; HYL tyrosine kinase; hematopoietic consensus tyrosine-lacking kinase; hydroxyaryl-protein kinase; leukocyte carboxyl-terminal src kinase related; protein kinase HYL; tyrosine kinase MATK; tyrosine-protein kinase CTK; tyrosylprotein kinase; EC 2.7.10.2
Gene ID : 4145
mRNA Refseq : NM_139354
Protein Refseq : NP_647611
MIM : 600038
UniProt ID : P42679

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