Recombinant Human MBNL1 protein, His/SUMO-tagged
Cat.No. : | MBNL1-6556H |
Product Overview : | Recombinant Human MBNL1 protein (1-382aa), fused to His/SUMO-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. |
Source : | E.coli |
Species : | Human |
Tag : | His/SUMO |
Form : | Liquid or Lyophilized powder. If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol; If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 57.0 kDa |
Protein length : | 382 |
AA Sequence : | MAVSVTPIRDTKWLTLEVCREFQRG TCSRPDTECKFAHPSKSCQVENGRV IACFDSLKGRCSRENCKYLHPPPHL KTQLEINGRNNLIQQKNMAMLAQQM QLANAMMPGAPLQPVPMFSVAPSLA TNASAAAFNPYLGPVSPSLVPAEIL PTAPMLVTGNPGVPVPAAAAAAAQK LMRTDRLEVCREYQRGNCNRGENDC RFAHPADSTMIDTNDNTVTVCMDYI KGRCSREKCKYFHPPAHLQAKIKAA QYQVNQAAAAQAAATAAAMGIPQAV LPPLPKRPALEKTNGATAVFNTGIF QYQQALANMQLQQHTAFLPPGSILC MTPATSVVPMVHGATPATVSAATTS ATSVPFAATATANQIPIISAEHLTS HKYVTQM |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Storage : | Store at -20 centigrade upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 centigrade/-80 centigrade. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | MBNL1 |
Official Symbol : | MBNL1 |
Synonyms : | EXP; MBNL |
Gene ID : | 4154 |
mRNA Refseq : | NM_021038.5 |
Protein Refseq : | NP_066368.2 |
MIM : | 606516 |
UniProt ID : | Q9NR56 |
Products Types
◆ Recombinant Protein | ||
MBNL1-241H | Recombinant Human MBNL1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Mbnl1-3982M | Recombinant Mouse Mbnl1 Protein, Myc/DDK-tagged | +Inquiry |
MBNL1-30258TH | Recombinant Human MBNL1 | +Inquiry |
MBNL1-2737H | Recombinant Human MBNL1, MYC/DDK-tagged | +Inquiry |
MBNL1-524H | Recombinant Human MBNL1 protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
MBNL1-4441HCL | Recombinant Human MBNL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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