Recombinant Human MBNL1 protein, MYC/DDK-tagged
Cat.No. : | MBNL1-524H |
Product Overview : | Recombinant Human MBNL1, transcript variant 6, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 36.8 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MBNL1 muscleblind-like splicing regulator 1 [ Homo sapiens ] |
Official Symbol : | MBNL1 |
Synonyms : | MBNL1; muscleblind-like splicing regulator 1; MBNL, muscleblind (Drosophila) like , muscleblind like (Drosophila); muscleblind-like protein 1; EXP; EXP35; EXP40; EXP42; KIAA0428; triplet-expansion RNA-binding protein; MBNL; DKFZp686P06174; |
Gene ID : | 4154 |
mRNA Refseq : | NM_207296 |
Protein Refseq : | NP_997179 |
MIM : | 606516 |
UniProt ID : | Q9NR56 |
Chromosome Location : | 3q25 |
Pathway : | Adipogenesis, organism-specific biosystem; |
Function : | RNA binding; double-stranded RNA binding; metal ion binding; nucleic acid binding; protein binding; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MBNL1-241H | Recombinant Human MBNL1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Mbnl1-3982M | Recombinant Mouse Mbnl1 Protein, Myc/DDK-tagged | +Inquiry |
MBNL1-2737H | Recombinant Human MBNL1, MYC/DDK-tagged | +Inquiry |
MBNL1-2736H | Recombinant Human MBNL1, MYC/DDK-tagged | +Inquiry |
MBNL1-3978C | Recombinant Chicken MBNL1 | +Inquiry |
◆ Lysates | ||
MBNL1-4441HCL | Recombinant Human MBNL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionIt contributes to tissue-specific splicing patterns, essential for proper development and function of various tissues.
MBNL1 regulates alternative splicing, polyadenylation, and localization of mRNAs, impacting gene expression.
MBNL1 plays a key role in muscle development and differentiation, influencing muscle-specific gene expression.
In myotonic dystrophy, MBNL1 becomes sequestered by toxic RNA repeats, leading to mis-splicing and muscular dysfunction.
Therapeutic modulation of MBNL1 is being explored, focusing on releasing MBNL1 from sequestration and correcting mis-splicing in conditions like myotonic dystrophy.
Sequestration of MBNL1 results in altered splicing patterns of numerous genes, contributing to cellular dysfunction.
There is limited information on post-translational modifications regulating MBNL1, necessitating further research.
Customer Reviews (3)
Write a reviewExcellent product, fast delivery.
Reliable for my research.
Worked perfectly, highly recommend.
Ask a Question for All MBNL1 Products
Required fields are marked with *
My Review for All MBNL1 Products
Required fields are marked with *
Inquiry Basket