| Description : |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91 kDa |
| AA Sequence : |
MAGTVVLDDVELREAQRDYLDFLDD EEDQGIYQSKVRELISDNQYRLIVN VNDLRRKNEKRANRLLNNAFEELVA FQRALKDFVASIDATYAKQYEEFYV GLEGSFGSKHVSPRTLTSCFLSCVV CVEGIVTKCSLVRPKVVRSVHYCPA TKKTIERRYSDLTTLVAFPSSSVYP TKDEENNPLETEYGLSVYKDHQTIT IQEMPEKAPAGQLPRSVDVILDDDL VDKAKPGDRVQVVGTYRCLPGKKGG YTSGTFRTVLIACNVKQMSKDAQPS FSAEDIAKIKKFSKTRSKDIFDQLA KSLAPSIHGHDYVKKAILCLLLGGV ERDLENGSHIRGDINILLIGDPSVA KSQLLRYVLCTAPRAIPTTGRGSSG VGLTAAVTTDQETGERRLEAGAMVL ADRGVVCIDEFDKMSDMDRTAIHEV MEQGRVTIAKAGIHARLNARCSVLA AANPVYGRYDQYKTPMENIGLQDSL LSRFDLLFIMLDQMDPEQDREISDH VLRMHRYRAPGEQDGDAMPLGSAVD ILATDDPNFSQEDQQDTQIYEKHDN LLHGTKKKKEKMVSAAFMKKYIHVA KIIKPVLTQESATYIAEEYSRLRSQ DSMSSDTARTSPVTARTLETLIRLA TAHAKARMSKTVDLQDAEEAVELVQ YAYFKKVLEKEKKRKKRSEDESETE DEEEKSQEDQEQKRKRRKTRQPDAK DGDSYDPYDFSDTEEEMPQVHTPKT ADSQETKESQKVELSESRLKAFKVA LLDVFREAHAQSIGMNRLTESINRD SEEPFSSVEIQAALSKMQDDNQVMV SEGIIFLITRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
