| Description : |
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
84.6 kDa |
| AA Sequence : |
MSFVAGVIRRLDETVVNRIAAGEVI QRPANAIKEMIENCLDAKSTSIQVI VKEGGLKLIQIQDNGTGIRKEDLDI VCERFTTSKLQSFEDLASISTYGFR GEALASISHVAHVTITTKTADGKCA YRASYSDGKLKAPPKPCAGNQGTQI TVEDLFYNIATRRKALKNPSEEYGK ILEVVGRYSVHNAGISFSVKKQGET VADVRTLPNASTVDNIRSIFGNAVS RELIEIGCEDKTLAFKMNGYISNAN YSVKKCIFLLFINHRLVESTSLRKA IETVYAAYLPKNTHPFLYLSLEISP QNVDVNVHPTKHEVHFLHEESILER VQQHIESKLLGSNSSRMYFTQTLLP GLAGPSGEMVKSTTSLTSSSTSGSS DKVYAHQMVRTDSREQKLDAFLQPL SKPLSSQPQAIVTEDKTDISSGRAR QQDEEMLELPAPAEVAAKNQSLEGD TTKGTSEMSEKRGPTSSNPRKRHRE DSDVEMVEDDSRKEMTAACTPRRRI INLTSVLSLQEEINEQGHEVLREML HNHSFVGCVNPQWALAQHQTKLYLL NTTKLSEELFYQILIYDFANFGVLR LSEPAPLFDLAMLALDSPESGWTEE DGPKEGLAEYIVEFLKKKAEMLADY FSLEIDEEGNLIGLPLLIDNYVPPL EGLPIFILRLATEVNWDEEKECFES LSKECAMFYSIRKQYISEESTLSGQ QSEVPGSIPNSWKWTVEHIVYKALR SHILPPKHFTEDGNILQLANLPDLY KVFERCTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
