Recombinant Human MMP11 Protein, Fc tagged

• Cat.No.: MMP11-20H
• Product Overview: Recombinant Human MMP11 Protein (Arg32-Leu488) with hFc (Glu99-Ala330) tag was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 32-488 aa
• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
• Form: Lyophilized from sterile Phosphate Buffered Saline, pH 7.4. Normally 5%–8% Trehalose is added as a protectant before lyophilization.
• Molecular Mass: 76.5 kDa
• Purity: > 95% by SDS-PAGE and Coomassie blue staining.
• Applications: SDS-PAGE
• Notes: This product is for research use only. It is not intended for diagnostic or therapeutic use.
• Storage: Shipped at 4 centigrade. Lyophilized: Store at -20 to -80 centigrade. Reconstituted: Aliquot and store at -80 centigrade. Product is stable for one year. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 [ Homo sapiens (human) ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11; ST3; SL-3; STMY3; stromelysin-3; matrix metallopeptidase 11 (stromelysin 3); stromelysin III; EC 3.4.24.-
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• UniProt ID: P24347